# Does adaption require a complex symphony or just “three chords and the truth?”

**Authors:** Klas I. Udekwu, Christopher J. Marx

PMC · DOI: 10.1371/journal.pbio.3003679 · PLOS Biology · 2026-03-27

## TL;DR

A study on yeast shows that adaptation has predictable effects on growth across different environments due to a limited number of key mutations.

## Contribution

The study reveals that adaptation in yeast involves only a few latent fitness-impacting phenotypes, making collateral effects predictable.

## Key findings

- Selected mutations in yeast affected only a few latent fitness-impacting phenotypes.
- Growth across environments was found to be fairly predictable based on these mutations.

## Abstract

How predictable are the collateral effects of adaptation? A new study of evolved yeast strains published in PLOS Biology suggests that growth across environments is fairly predictable because the selected mutations only affected a few latent fitness-impacting phenotypes.

How predictable are the collateral effects of adaptation? This Primer explores a new PLOS Biology study of evolved yeast strains suggesting that growth across environments is fairly predictable because the selected mutations only affected a few latent fitness-impacting phenotypes.

## Full-text entities

- **Chemicals:** cAMP (-), (p)ppGpp (MESH:D006158), lactose (MESH:D007785)
- **Species:** Saccharomyces cerevisiae (baker's yeast, species) [taxon 4932]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC13028505/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC13028505/full.md

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Source: https://tomesphere.com/paper/PMC13028505