# Machine Learning in Adapted Physical Activity: Clinical Applications, Monitoring, and Implementation Pathways for Personalized Exercise in Chronic Conditions: A Narrative Review

**Authors:** Gianpiero Greco, Alessandro Petrelli, Luca Poli, Francesco Fischetti, Stefania Cataldi

PMC · DOI: 10.3390/jfmk11010106 · Journal of Functional Morphology and Kinesiology · 2026-03-04

## TL;DR

This review explores how machine learning can support personalized exercise for people with chronic conditions, focusing on clinical applications and ethical considerations.

## Contribution

The paper provides a comprehensive synthesis of machine learning applications in adapted physical activity for chronic conditions.

## Key findings

- ML supports markerless motion analysis, wearable data processing, and fall-risk assessment in adapted physical activity.
- Predictive models enable individualized exercise regulation and remote delivery for diverse chronic conditions.
- Ethical issues like algorithmic bias and data privacy are critical for responsible ML implementation in APA.

## Abstract

Machine learning (ML) is increasingly influencing the assessment and delivery of movement and exercise, yet its role within adapted physical activity (APA) for individuals with chronic conditions has not been comprehensively synthesized. ML-based approaches have the potential to enhance functional assessment, support individualized exercise prescription, and facilitate scalable monitoring across preventive, community-based, and long-term adapted exercise settings, particularly in populations characterized by functional heterogeneity and variable responses to exercise. The aim of this narrative review is to synthesize and critically discuss current ML applications relevant to the core professional processes of APA practice. A structured narrative review was conducted using searches in PubMed/MEDLINE, Scopus, and Web of Science, complemented by targeted searches in engineering-oriented sources to capture ML methods not consistently indexed in biomedical databases. The search covered the period in which contemporary ML approaches have been increasingly applied to human movement and exercise research and was last updated in January 2026. Evidence was synthesized thematically into application-oriented domains relevant to APA practice. ML applications in APA include markerless motion and gait analysis, wearable-sensor data processing, balance and fall-risk assessment, and functional classification. Predictive and adaptive models support individualized regulation of exercise intensity, progression, and workload, including remote and hybrid delivery models. Applications span oncology, cardiometabolic, respiratory, neuromuscular conditions, and adapted sport contexts. Ethical, legal, and governance issues, such as algorithmic bias, data privacy, and professional accountability, emerge as central considerations for safe and equitable implementation. ML represents a promising decision-support layer for APA, complementing professional expertise through enhanced assessment, personalization, and monitoring. Its effective integration requires robust validation, interpretability, and responsible governance to ensure that ML augments, rather than replaces, professional judgment in APA practice.

## Full-text entities

- **Diseases:** Chronic Conditions (MESH:D002908)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

95 references — full list in the complete paper: https://tomesphere.com/paper/PMC13028406/full.md

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Source: https://tomesphere.com/paper/PMC13028406