# Unraveling the Complexities of Small Intestinal Bacterial Overgrowth

**Authors:** Enrico Capuano, Angelo Del Gaudio, Enrico Celestino Nista, Sara Sofia De Lucia, Antonio Pellegrino, Giuseppe Cuccia, Angela Saviano, Carmine Petruzziello, Veronica Ojetti

PMC · DOI: 10.3390/medicina62030485 · Medicina · 2026-03-04

## TL;DR

This review explains the causes, diagnosis, and treatment of Small Intestinal Bacterial Overgrowth (SIBO) to improve understanding and management of the condition.

## Contribution

The paper synthesizes recent research to clarify SIBO's complexities and guide effective clinical strategies.

## Key findings

- SIBO is linked to gastrointestinal disorders and gut motility issues.
- Breath testing and direct aspiration are key diagnostic methods with distinct advantages.
- Treatment includes antibiotics, diet changes, and new therapies under investigation.

## Abstract

This narrative review explores the intricate dynamics of Small Intestinal Bacterial Overgrowth (SIBO), a condition marked by an excessive growth of bacteria in the small intestine. We delve into the multifaceted etiology of SIBO, including its associations with gastrointestinal disorders, motility issues, and alterations in gut architecture. The review examines current diagnostic methodologies, emphasizing the distinctions between breath testing and direct aspiration techniques. Furthermore, we assess the various treatment approaches, ranging from antibiotics and dietary modifications to emerging therapeutic options. By synthesizing the latest research findings, we aim to enhance understanding of SIBO’s implications for gut health and provide insights into effective management strategies.

## Linked entities

- **Diseases:** Small Intestinal Bacterial Overgrowth (MONDO:0400000)

## Full-text entities

- **Diseases:** SIBO (MESH:D001765), gastrointestinal disorders (MESH:D005767)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC13028015/full.md

## References

145 references — full list in the complete paper: https://tomesphere.com/paper/PMC13028015/full.md

---
Source: https://tomesphere.com/paper/PMC13028015