The Combined Benefits of Definisse™ Revitalise Threads and Definisse [KP1]® Redensifying Cream Treatments: A 19-Patient Case Series

TL;DR

This study shows that combining a thread treatment with a peptide cream improves facial rejuvenation and skin satisfaction in patients.

Contribution

The study introduces a novel combination of a thread treatment and a peptide-based cream for enhanced facial rejuvenation.

Findings

Patients reported significant improvements in skin satisfaction and perceived aging after treatment.

The addition of the peptide cream enhanced skin quality beyond the thread treatment alone.

The combination was well-tolerated with no serious adverse events reported.

Abstract

Peptides, particularly SA1-III decapeptide, play a key role in maintaining skin structure by inhibiting collagen degradation. The aim of this analysis was to investigate the combined effects of Definisse™ Revitalise Threads and Definisse [KP1]® Redensifying Cream containing SA1-III for facial rejuvenation. Patients receiving Definisse™ Revitalise Threads were offered Definisse™ Redensifying Cream for one month. Outcomes—including efficacy, safety, and patient satisfaction—were assessed over six months using 3D imaging, clinical evaluation, and the FACE-Q™ questionnaire. Due to the sample size, data were summarised descriptively, with group comparisons using exact Mann–Whitney U tests and paired analyses using the Wilcoxon signed-rank test (p < 0.05). Nineteen individuals underwent treatment with Definisse™ Revitalise Threads (17 females and 2 males, aged 38–72 years); 10 patients used additional Definisse [KP1]® Redensifying Cream while 9 did not. All patients reported significant improvements in skin satisfaction, cheek fullness, and perceived aging, based in FACE-QTM scores before and after treatment. Thread treatment visibly improved facial appearance, but the addition of the peptide-containing cream further enhanced skin quality. Indeed, greater improvements in skin satisfaction were reported by individuals using vs. not using Definisse [KP1]® Redensifying Cream. No adverse events were reported, and the FACE-QTM Adverse Effects scale indicated only mild, transient effects. In this preliminary series with a six-month follow-up, the combination of Definisse Revitalise Threads and Definisse® Redensifying Cream was well-tolerated and showed potential for enhancing facial rejuvenation. These preliminary findings suggest that peptide-based cosmeceuticals may complement aesthetic procedures and support skin health. These preliminary results will be used to generate hypotheses for larger studies with longer follow-up, which are needed to confirm these effects.

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