# Total Ankle Replacement Through a Lateral Transfibular Approach in Patients with Ipsilateral Knee Arthrodesis: Report of Two Cases

**Authors:** Carla Carfì, Serban-Andrei Constantinescu, Cristian Indino, Federico Della Rocca, Camilla Maccario, Federico Giuseppe Usuelli

PMC · DOI: 10.3390/jcm15062094 · 2026-03-10

## TL;DR

This paper reports successful total ankle replacement in two patients with a fused knee, showing pain relief and improved mobility.

## Contribution

The study presents the first reported cases of TAR using a lateral transfibular approach in patients with ipsilateral knee arthrodesis.

## Key findings

- Both patients experienced significant pain reduction and improved ankle range of motion.
- Stable, functional gait was achieved without major complications or reoperations.
- Imaging showed well-aligned, stable implants with no loosening or subsidence.

## Abstract

Background: Knee arthrodesis markedly alters lower limb biomechanics and creates a challenging scenario when associated with end-stage ankle osteoarthritis. No prior reports have specifically described treatment with total ankle replacement (TAR) in the presence of an ipsilateral fused knee. This study evaluated the feasibility and mid-term outcomes of TAR in this rare condition. Methods: Two patients with post-traumatic end-stage ankle osteoarthritis and long-standing knee arthrodesis underwent TAR using a lateral transfibular approach with a Zimmer Trabecular Metal™ implant. Surgical planning aimed to restore coronal and sagittal alignment. Postoperative management and rehabilitation were specifically adapted to the absence of knee motion, with emphasis on gait re-education. Clinical and radiographic follow-up was performed up to 36 months. Results: At final follow-up, both patients showed substantial pain reduction, improved ankle range of motion, and recovery of a stable, functional gait compatible with knee fusion. Imaging demonstrated well-aligned, stable components without loosening or subsidence. No major complications or reoperations occurred. Conclusions: Lateral transfibular TAR appears feasible and effective for end-stage ankle osteoarthritis in patients with ipsilateral knee arthrodesis, preserving ankle motion and supporting functional ambulation in this complex setting.

## Linked entities

- **Diseases:** osteoarthritis (MONDO:0005178)

## Full-text entities

- **Diseases:** absence of (MESH:D004832), pain (MESH:D010146), end-stage ankle osteoarthritis (MESH:D007676)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13027282/full.md

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Source: https://tomesphere.com/paper/PMC13027282