Birth Prevalence of Sickle Cell Disease in India: A Systematic Review and Meta-Analysis

TL;DR

This study estimates the birth prevalence of sickle cell disease in India using data from newborn screening reports.

Contribution

The study provides pooled prevalence estimates of sickle cell disease and trait in newborns in India.

Findings

The pooled prevalence of sickle cell disease was 1100 per 100,000 in endemic regions.

Sickle cell trait prevalence was 9639 per 100,000 in endemic regions.

Data on long-term outcomes and cost-effectiveness remain limited.

Abstract

Newborn screening helps identify sickle cell disorder (SCD) early and to promptly initiate effective measures. It is estimated that India accounts for approximately 16% of global annual births with SCD. Multiple reports of screening for SCD in India have emerged in the last decade. Our aim was to pool the birth prevalence of SCD and sickle cell trait (SCT). A systematic review of published evidence on nontargeted, universal screening for SCD or SCT in newborns was performed (16 studies). The pooled prevalence of SCD was 1100 per 100,000 (10 studies, 88,276 neonates, 95% CI: 432, 1768), while that of SCT was 9639 per 100,000 (7 studies, 72,702 neonates, 95% CI: 6283, 12,995) in endemic regions. Limited data exist from nonendemic regions. Only three studies had data on follow-up and confirmatory genetic diagnosis. Sparse data exist on cost-effectiveness, long-term follow-up, and the impact of early screening on mortality. Concerted ongoing efforts in the identification of the burden are needed. The needs of the hour are universalization of NBS, integration into existing health systems, and maintenance of birth cohorts with early introduction of penicillin prophylaxis, hydroxyurea, parental education, appropriate immunization, and continued follow-up by an experienced medical team.

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