# Heart Failure and a Large Ventricular Thrombus Following COVID-19 Infection

**Authors:** Jouni Taavitsainen, Ville Vepsäläinen, Juha Hartikainen, Jarkko Hytönen

PMC · DOI: 10.3390/jcdd13030139 · Journal of Cardiovascular Development and Disease · 2026-03-13

## TL;DR

A 67-year-old man developed severe heart failure and a large blood clot in his heart after a COVID-19 infection, requiring strong anti-inflammatory treatment for recovery.

## Contribution

This case highlights the rare but severe complication of intraventricular thrombosis following COVID-19 and the need for anti-inflammatory therapy.

## Key findings

- The patient developed a massive left ventricular thrombus after a COVID-19 infection.
- Heart failure improved with anti-inflammatory medication and standard treatment.
- The thrombus resolved without embolic events, but recovery was prolonged due to complications.

## Abstract

Severe cases of heart failure (HF), both new onsets of HF and acute exacerbations of chronic HF, are frequently observed during infections. A potentially lethal complication of HF with very low left ventricular ejection fraction is thrombus formation within the heart chambers. A 67-year-old male was admitted to our hospital with shortness of breath after a COVID-19 infection. He was diagnosed with severe acute heart failure and a massive thrombus in the left ventricle. While the thrombus subsided quickly without any observable embolic events, the patient had a lengthy hospitalization stay complicated by tachyarrhythmias and secondary infections. Eventually, his heart failure improved, and he continued to recover post-hospital discharge. We present a case of severe heart failure and intraventricular thrombosis following COVID-19 infection. The patient required potent anti-inflammatory medication in addition to conventional heart failure medication to recover from his HF.

## Linked entities

- **Diseases:** heart failure (MONDO:0005252), COVID-19 (MONDO:0100096)

## Full-text entities

- **Genes:** CD68 (CD68 molecule) [NCBI Gene 968] {aka GP110, LAMP4, SCARD1}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, TNNT1 (troponin T1, slow skeletal type) [NCBI Gene 7138] {aka ANM, NEM5, STNT, TNT, TNTS}, F10 (coagulation factor X) [NCBI Gene 2159] {aka FX, FXA}, PTPRC (protein tyrosine phosphatase receptor type C) [NCBI Gene 5788] {aka B220, CD45, CD45R, GP180, IMD105, L-CA}
- **Diseases:** blood stasis (MESH:D014647), fever (MESH:D005334), HF (MESH:D006333), hypercoagulability (MESH:D019851), thromboembolic (MESH:D013923), pleural effusion (MESH:D010996), temporal arteritis (MESH:D013700), embolic events (MESH:D004617), intraventricular thrombosis (MESH:D006345), COVID-19 (MESH:D000086382), edema (MESH:D004487), vomiting (MESH:D014839), ventricular tachycardia (MESH:D017180), thrombocytopenia (MESH:D013921), renal failure (MESH:D051437), arrhythmias (MESH:D001145), Inflammatory (MESH:D007249), LV thrombus (MESH:D013927), LV thrombosis (MESH:D018487), chest pain (MESH:D002637), multi-organ failure (MESH:D009102), viral (MESH:D014777), LV mass (MESH:C536030), atrial fibrillation (MESH:D001281), sinus tachycardia (MESH:D013616), malignancy (MESH:D009369), ventricular (MESH:D014693), lymphocytic myocarditis (MESH:D009205), atrial flutter (MESH:D001282), endothelial (MESH:D005642), bladder cancer (MESH:D001749), cardiogenic shock (MESH:D012770), atrial tachycardia (MESH:D013617), COPD (MESH:D029424), tachyarrhythmia (MESH:D013610), dyspnea (MESH:D004417), smoker (MESH:C000719328), acidosis (MESH:D000138), iritis (MESH:D007500), injury to (MESH:D014947), infected (MESH:D007239), nausea (MESH:D009325), NSVT (MESH:D013614), heart disease (MESH:D006331), pneumonia (MESH:D011014), hypotension (MESH:D007022)
- **Chemicals:** enoxaparin (MESH:D017984), EMB (MESH:D004977), Steroid (MESH:D013256), apixaban (MESH:C522181), valsartan (MESH:D000068756), gemcitabine (MESH:D000093542), sacubitril (MESH:C000717211), levosimendan (MESH:D000077464), ciprofloxacin (MESH:D002939), creatinine (MESH:D003404), warfarin (MESH:D014859), LMWH (MESH:D006495), Piperacillin/tazobactam (MESH:D000077725), tinzaparin (MESH:D000078222), heparin (MESH:D006493), metoprolol (MESH:D008790), cisplatin (MESH:D002945), Prednisolone (MESH:D011239), amiodarone (MESH:D000638), vasoactive agents (-), methylprednisolone (MESH:D008775)
- **Species:** Serratia marcescens (species) [taxon 615], Homo sapiens (human, species) [taxon 9606], Klebsiella aerogenes (species) [taxon 548]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC13026141/full.md

## References

16 references — full list in the complete paper: https://tomesphere.com/paper/PMC13026141/full.md

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Source: https://tomesphere.com/paper/PMC13026141