# Rheology and Amylase Resistance of Calcium-Enriched Calorie-Dense Emulsions for Dysphagia Management

**Authors:** Huaiwen Yang, Yi-Zhen Shen

PMC · DOI: 10.3390/gels12030192 · Gels · 2026-02-25

## TL;DR

This study explores how adding calcium and adjusting thickener ratios can improve the texture and stability of calorie-dense foods for people with swallowing difficulties.

## Contribution

The novel contribution is identifying how calcium sources and thickener ratios affect emulsion resistance to saliva and α-amylase degradation.

## Key findings

- A 1:4 LBG:RF emulsion maintained suitable viscosity after saliva dilution.
- Calcium from lactate and gluconate enhanced resistance to α-amylase degradation.
- The 1:4 LBG:RF emulsion showed the least degradation after simulated saliva treatment.

## Abstract

This study examines how changes in salivary α-amylase and calcium affect the rheological properties and stability of food emulsions thickened with Locust Bean Gum (LBG) and Pre-gelatinized Rice Flour (RF), containing 10% Medium-chain Triglycerides (MCT). Increasing the LBG: RF ratio improves resistance to simulated saliva dilution. The 1:4 (LBG: RF) emulsion maintained an apparent viscosity within the NDD nectar-like range after simulated saliva addition, making it suitable for patients with dysphagia. Calcium sources from lactate (LC) and gluconate (GC) enhanced the emulsion’s resistance to α-amylase degradation, especially at a shear rate of 10 s−1. The study also evaluated levels according to the International Dysphagia Diet Standardisation Initiative (IDDSI). Both NDD honey-like and pudding-like samples were classified as IDDSI Level 3 by the syringe test, showing that different grading systems and food compositions can lead to variations. After simulated saliva treatment, the 1:4 (LBG: RF) sample showed the least degradation. These findings highlight the significant role of salivary α-amylase in thickened foods and emphasize the importance of optimizing thickener types and formulation ratios to enhance dietary safety for individuals with dysphagia.

## Linked entities

- **Chemicals:** calcium lactate (PubChem CID 13144), calcium gluconate (PubChem CID 9290)

## Full-text entities

- **Genes:** GGH (gamma-glutamyl hydrolase) [NCBI Gene 8836] {aka GATD10, GH}, INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}, GH1 (growth hormone 1) [NCBI Gene 2688] {aka GH, GH-N, GHB5, GHN, IGHD1A, IGHD1B}
- **Diseases:** Dysphagia (MESH:D003680), choking (MESH:D000402), calcium loss (MESH:D002128), LC (MESH:D007775), neurodegenerative conditions (MESH:D019636), aspiration (MESH:D011015), sarcopenia (MESH:D055948), pulmonary aspiration (MESH:D053120), malnutrition (MESH:D044342), stroke (MESH:D020521), injury to (MESH:D014947)
- **Chemicals:** lactates (MESH:D007773), water (MESH:D014867), Calcium Gluconate (MESH:D002125), copper (MESH:D003300), mannose (MESH:D008358), HCl (MESH:D006851), NaHCO3 (MESH:D017693), carbohydrate (MESH:D002241), carbonate (MESH:D002254), GC (MESH:C030691), salt (MESH:D012492), oil (MESH:D009821), MCTs (MESH:C000709826), Calcium Lactate (MESH:C110051), K2HPO4 (MESH:C013216), amylose (MESH:D000688), Calcium Carbonate (MESH:D002119), calcium chloride dihydrate (MESH:D002122), Starch (MESH:D013213), polysaccharide (MESH:D011134), NaOH (MESH:D012972), (NH4)2CO3 (MESH:C040502), galactose (MESH:D005690), Lipids (MESH:D008055), galactomannans (MESH:C012990), Magnesium chloride hexahydrate (MESH:D015636), TL (MESH:D013793), LC (MESH:D019344), KCl (MESH:D011189), LBG (MESH:C017471), acids (MESH:D000143), hydrogen (MESH:D006859), Calcium (MESH:D002118), CC (-)
- **Species:** Chenopodium quinoa (quinoa, species) [taxon 63459], Lepraria sp. BG (species) [taxon 408679], Homo sapiens (human, species) [taxon 9606], Oryza sativa (Asian cultivated rice, species) [taxon 4530]
- **Cell lines:** HL1R4 — Mus musculus (Mouse), Transformed cell line (CVCL_0303), HL1R0.5 — Mus musculus (Mouse), Malignant neoplasms of the mouse mammary gland, Cancer cell line (CVCL_0I88), HL1R8 — Paralichthys olivaceus (Bastard halibut), Transformed cell line (CVCL_B6DX)

## Full text

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## Figures

11 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13026073/full.md

## References

57 references — full list in the complete paper: https://tomesphere.com/paper/PMC13026073/full.md

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Source: https://tomesphere.com/paper/PMC13026073