Unrecognized Atrial Septal Defect Presenting with Postoperative Occipital Infarction
Jasper Lin, Vinicius Carraro do Nascimento, Jeremy Hefford, Tony Vo, Maria Gabriela Matta

TL;DR
A woman's post-surgery stroke was linked to an undetected heart defect, showing how hidden heart issues can cause strokes.
Contribution
This case highlights the importance of multimodal imaging in diagnosing occult atrial septal defects as a cause of cryptogenic stroke.
Findings
A 4.6 mm ostium secundum atrial septal defect was identified as the source of embolic stroke.
Percutaneous closure of the defect resolved the shunt and prevented further complications.
Multimodal imaging confirmed the presence of an interatrial shunt and guided treatment.
Abstract
A 49-year-old woman developed acute homonymous hemianopia three days after elective surgery. Neuroimaging confirmed an embolic right occipital infarction. Transthoracic echocardiography demonstrated early bubble passage, and transesophageal imaging identified a 4.6 mm ostium secundum atrial septal defect. The defect was successfully closed percutaneously with complete shunt resolution. This case emphasizes the value of targeted multimodality imaging in uncovering occult interatrial shunts and highlights presumed paradoxical embolism as a potential mechanism of postoperative or cryptogenic stroke.
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsCardiovascular and Diving-Related Complications · Cardiac and Coronary Surgery Techniques · Infective Endocarditis Diagnosis and Management
The reference list from the paper itself. Each links out to its DOI / PubMed record.
- 1Alemseged F. Rocco A. Arba F. Schwabova J.P. Wu T. Cavicchia L. Ng F. Ng J.L. Zhao H. Williams C. Posterior National Institutes of Health Stroke Scale improves prognostic accuracy in posterior circulation stroke Stroke 2022531247125510.1161/STROKEAHA.120.03401934905944 · doi ↗ · pubmed ↗
- 2Go S. Posterior circulation ischemic stroke Mo. Med.201511219210.5005/jp-journals-10045-005826168589 PMC 6170115 · doi ↗ · pubmed ↗
- 3Grewal K. Austin P.C. Kapral M.K. Lu H. Atzema C.L. Missed strokes using computed tomography imaging in patients with vertigo: A population-based cohort study Stroke 20154610811310.1161/STROKEAHA.114.00708725477217 · doi ↗ · pubmed ↗
- 4Imam Y.Z. Chandra P. Singh R. Hakeem I. Al Sirhan S. Kotob M. Akhtar N. Kamran S. Al Jerdi S. Muhammad A. Incidence, clinical features, and outcomes of posterior circulation ischemic stroke: Insights from a large multiethnic stroke database Front. Neurol.202415130229810.3389/fneur.2024.130229838385041 PMC 10879388 · doi ↗ · pubmed ↗
- 5Caplan L.R. Wityk R.J. Glass T.A. Tapia J. Pazdera L. Chang H.M. Teal P. Dashe J.F. Chaves C.J. Breen J.C. New England Medical Center posterior circulation registry Ann. Neurol.20045638939810.1002/ana.2020415349866 · doi ↗ · pubmed ↗
- 6Bernard S. Churchill T.W. Namasivayam M. Bertrand P.B. Agitated saline contrast echocardiography in the identification of intra- and extracardiac shunts: Connecting the dots J. Am. Soc. Echocardiogr.20213411210.1016/j.echo.2020.09.01334756394 · doi ↗ · pubmed ↗
- 7Lin J. Carraro do Nascimento V. Hefford J. Vo T. Matta M.G. Coronary embolism from a sinus venosus atrial septal defect with partial anomalous pulmonary venous drainage JACC Case Rep.2025303010.1016/j.jaccas.2025.105220 · doi ↗
- 8Tighe D.A. Aurigemma G.P. Right-to-left shunts and saline contrast echocardiography Chest 201013824624810.1378/chest.10-042020682525 · doi ↗ · pubmed ↗
