# Microneedles: Selected Applications for Pediatrics

**Authors:** Alexis A. Ayala, Hassan Almoazen

PMC · DOI: 10.3390/children13030360 · Children · 2026-03-02

## TL;DR

Microneedles offer a promising, child-friendly way to deliver drugs and vaccines through the skin, making medical treatments less painful for children.

## Contribution

The paper reviews novel pediatric applications of microneedles for drug and vaccine delivery.

## Key findings

- Microneedles can deliver large molecules like proteins and nucleotides through the skin.
- They are being explored for use in vaccines and diagnostics for children.
- The potential for expanding microneedle applications to other body sites is highlighted.

## Abstract

Microneedles are a pediatric-friendly drug delivery system that has attracted many novel research endeavors. The fact that it creates a tiny cavity in the epidermis, which can allow peptides, proteins, nucleotides, and other large-sized molecules to penetrate the skin barrier, is very advantageous for transdermal delivery. In this review article, we shed light on several pediatric applications of microneedles, such as the delivery of proteins, vaccines, and diagnostics. We believe the advantages of microneedles will continue to expand and be applied to other sites in the body.

## Full-text entities

- **Chemicals:** nucleotides (MESH:D009711)

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13026018/full.md

## References

50 references — full list in the complete paper: https://tomesphere.com/paper/PMC13026018/full.md

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Source: https://tomesphere.com/paper/PMC13026018