# Trogocytosis and Allergy

## TL;DR

Trogocytosis, a process where cells exchange membrane fragments, influences immune balance and may contribute to allergies or tolerance.

## Contribution

This review highlights how trogocytosis involves T2 immunity and its dual role in promoting allergies and inducing tolerance.

## Key findings

- Trogocytosis transfers MHC and costimulatory molecules like CD80 and CD86 between cells.
- Trogocytosis may shift immune responses toward T2, contributing to allergic diseases.
- Trogocytosis could also help develop tolerance to allergens.

## Abstract

What are the main findings?
Trogocytosis is a cell interaction process that influences immune responses in health and disease, including allergies.Trogocytosis affects immune balance.

Trogocytosis is a cell interaction process that influences immune responses in health and disease, including allergies.

Trogocytosis affects immune balance.

What are the implications of main findings?
Trogocytosis may shift immune responses toward T2 and contribute to the development of T2 allergic diseases.Trogocytosis may also contribute to the development of tolerance to an allergen.

Trogocytosis may shift immune responses toward T2 and contribute to the development of T2 allergic diseases.

Trogocytosis may also contribute to the development of tolerance to an allergen.

Trogocytosis is the process of engulfment of a portion of a cell’s membrane by another cell. This process is characterized by the transfer of membrane fragments and proteins between adjacent cells without their complete fusion or phagocytosis, which distinguishes it from classical cellular uptake pathways. In the immune system, the initiating signal for trogocytosis is antigen presentation or the interaction of the Fc receptor with an antibody bound to the cell. During trogocytosis, T cells transfer not only the MHC molecule with the antigenic peptide, but also the costimulatory molecules CD80, CD86, OX-40 and others. As a result of trogocytosis, cells can transfer various surface molecules, acquire new immunological properties, and modulate each other’s activity. This review examines the basic mechanisms of trogocytosis, the involvement of T2-mediated immunity components in trogocytosis, and its possible role in allergies.