# Polymeric Nanogels for Antimicrobial Therapy

**Authors:** M. Cristina Ibarra-Alonso, Sofía Estrada-Flores, Alejandra E. Herrera-Alonso, Elsa Nadia Aguilera-González, Antonia Martínez-Luévanos

PMC · DOI: 10.3390/gels12030264 · Gels · 2026-03-22

## TL;DR

This paper reviews how polymeric nanogels can be used for antimicrobial therapy, highlighting their benefits and preparation methods.

## Contribution

The paper provides a comprehensive review of polymeric nanogels for antimicrobial therapy, focusing on their types, advantages, and preparation methodologies.

## Key findings

- Polymeric nanogels show antimicrobial activity and are suitable for drug delivery and wound dressings.
- Nanogels offer advantages like biocompatibility, biodegradability, and swelling properties.
- Different preparation methods for nanogels are analyzed for their effectiveness in antimicrobial applications.

## Abstract

At present, the development of antimicrobial systems requires ongoing and consistent improvement in their efficacy and versatility. Polymeric nanogels can serve as an efficient tool for this purpose, as they have become an excellent alternative for the design of tissue engineering and bone regeneration scaffolds, in addition to vehicles for the delivery of drugs or active substances, and they have recently been investigated as wound dressings. Nanogels have also been shown to be an excellent alternative for nanomedicine due to their antimicrobial activity and specific properties, such as swelling, biocompatibility, and biodegradability. In this review, we present an analysis of the use of polymeric nanogels for antimicrobial therapy and provide a discussion focused on different types of nanogels and their advantages and disadvantages, which will serve as a reference point for the future development of nanogels with antimicrobial properties. We also focus on the analysis of the different methodologies employed to prepare nanogels.

## Full-text entities

- **Diseases:** inflammatory (MESH:D007249), bacterial infections (MESH:D001424), injury to (MESH:D014947), infection (MESH:D007239), cytotoxicity (MESH:D064420)
- **Chemicals:** oil (MESH:D009821), Genipin (MESH:C007834), MPS (MESH:C063925), Vancomycin (MESH:D014640), H2O2 (MESH:D006861), oxides (MESH:D010087), PEG (MESH:D011092), OH* (MESH:C031356), MAC (MESH:D008299), rifaximin (MESH:D000078262), minocycline (MESH:D008911), GSH (MESH:D005978), butyl acrylate (MESH:C032490), ciprofloxacin (MESH:D002939), TNG (MESH:D005996), ROS (MESH:D017382), carboxymethyl CS (MESH:C514968), PMMA (MESH:D019904), silica (MESH:D012822), 3-(trimethoxysilyl)propyl methacrylate (MESH:C505504), water (MESH:D014867), polyacrylamide (MESH:C016679), Cu2O (MESH:C000520), poly(N-vinylcaprolactam) (MESH:C086861), guar gum (MESH:C007894), Cu (MESH:D003300), PMAA (MESH:C030613), alginate (MESH:D000464), cellulose (MESH:D002482), thymol (MESH:D013943), Metal (MESH:D008670), cystamine (MESH:D003538), acrylic acid (MESH:C036658), ATP (MESH:D000255), TA (MESH:C021751), glycidyl methacrylate (MESH:C007870), carboxymethylcellulose (MESH:D002266), PCL (MESH:C016240), CTAB (MESH:D000077286), polyvinyl alcohol (MESH:D011142), O2* (MESH:D010100), Nanogels (MESH:D000080385), Amox (MESH:D000658), AAm (MESH:D020106), Pluronic F127 (MESH:D020442), triclosan (MESH:D014260), disulfide (MESH:D004220), thiol (MESH:D013438), TPP (MESH:C005692), PNIPAM (MESH:C052970), isoniazid (MESH:D007538), hydrogen (MESH:D006859), borate (MESH:D001881), MgO (MESH:D008277), cholesterol (MESH:D002784), methicillin (MESH:D008712), PDPA (-), NO (MESH:D009569), Mupirocin (MESH:D016712), Polymer (MESH:D011108)
- **Species:** Salvia miltiorrhiza (Chinese salvia, species) [taxon 226208], Salmonella enterica subsp. enterica serovar Typhimurium (no rank) [taxon 90371], Escherichia coli (E. coli, species) [taxon 562], Bacteria Latreille et al. 1825 (Bacteria stick insect, genus) [taxon 629395], Streptococcus mutans (species) [taxon 1309], Citrus x limon (lemon, species) [taxon 2708], Staphylococcus aureus (species) [taxon 1280], Cutibacterium acnes (species) [taxon 1747], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

8 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13025931/full.md

## References

77 references — full list in the complete paper: https://tomesphere.com/paper/PMC13025931/full.md

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Source: https://tomesphere.com/paper/PMC13025931