# Editorial for Special Issue: “Molecular Mechanisms Underlying Fatty Liver Disease: From Pathogenesis to Treatment, 2nd Edition”

**Authors:** Wei Guo, Haibo Dong

PMC · DOI: 10.3390/cimb48030288 · 2026-03-09

## Full-text entities

- **Genes:** PHGDH (phosphoglycerate dehydrogenase) [NCBI Gene 26227] {aka 3-PGDH, 3PGDH, HEL-S-113, NLS, NLS1, PDG}, STING1 (stimulator of interferon response cGAMP interactor 1) [NCBI Gene 340061] {aka ERIS, MITA, MPYS, NET23, SAVI, STING}, NFKB1 (nuclear factor kappa B subunit 1) [NCBI Gene 4790] {aka CVID12, EBP-1, KBF1, NF-kB, NF-kB1, NF-kappa-B1}, ACTA1 (actin alpha 1, skeletal muscle) [NCBI Gene 58] {aka ACTA, ASMA, CFTD, CFTD1, CFTDM, CMYO2A}, TBK1 (TANK binding kinase 1) [NCBI Gene 29110] {aka AIARV, FTDALS4, IIAE8, NAK, T2K}, IRF3 (interferon regulatory factor 3) [NCBI Gene 3661] {aka IIAE7}, IRF1 (interferon regulatory factor 1) [NCBI Gene 3659] {aka IMD117, IRF-1, MAR}, DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A) [NCBI Gene 1859] {aka DYRK, DYRK1, HP86, MNB, MNBH, MRD7}, FTO (FTO alpha-ketoglutarate dependent dioxygenase) [NCBI Gene 79068] {aka ALKBH9, BMIQ14, GDFD, IFEX9}, FUT4 (fucosyltransferase 4) [NCBI Gene 2526] {aka CD15, ELFT, FCT3A, FUC-TIV, FUTIV, LeX}, TLR4 (toll like receptor 4) [NCBI Gene 7099] {aka ARMD10, CD284, TLR-4, TOLL}, SLC5A2 (solute carrier family 5 member 2) [NCBI Gene 6524] {aka SGLT2}, TIMP1 (TIMP metallopeptidase inhibitor 1) [NCBI Gene 7076] {aka CLGI, EPA, EPO, HCI, TIMP, TIMP-1}, MMP9 (matrix metallopeptidase 9) [NCBI Gene 4318] {aka CLG4B, GELB, MANDP2, MMP-9}, ABCB1 (ATP binding cassette subfamily B member 1) [NCBI Gene 5243] {aka ABC20, CD243, CLCS, ENPAT, GP170, MDR1}, COL1A1 (collagen type I alpha 1 chain) [NCBI Gene 1277] {aka CAFYD, EDSARTH1, EDSC, OI1, OI2, OI3}, IRF9 (interferon regulatory factor 9) [NCBI Gene 10379] {aka IRF-9, ISGF3, ISGF3G, p48}, IL22 (interleukin 22) [NCBI Gene 50616] {aka IL-21, IL-22, IL-D110, IL-TIF, ILTIF, TIFIL-23}, IRF4 (interferon regulatory factor 4) [NCBI Gene 3662] {aka IMD131, LSIRF, MUM1, NF-EM5, SHEP8}, TLR9 (toll like receptor 9) [NCBI Gene 54106] {aka CD289}, IRF5 (interferon regulatory factor 5) [NCBI Gene 3663] {aka SLEB10}, CGAS (cyclic GMP-AMP synthase) [NCBI Gene 115004] {aka C6orf150, D4, MB21D1, h-cGAS}, IRF7 (interferon regulatory factor 7) [NCBI Gene 3665] {aka IMD39, IRF-7, IRF-7H, IRF7A, IRF7B, IRF7C}, PNPLA3 (patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase) [NCBI Gene 80339] {aka ADPN, C22orf20, iPLA(2)epsilon}
- **Diseases:** hypothyroidism (MESH:D007037), obese (MESH:D009765), non-alcoholic fatty liver disease (MESH:D065626), DD (MESH:D003866), injury to (MESH:D014947), insulin resistance (MESH:D007333), Endocrine disorders (MESH:D004700), systemic (MESH:D015619), hypercortisolism (MESH:D003480), cirrhosis (MESH:D005355), ALD (MESH:D008108), metabolic disorders (MESH:D008659), COVID-19 (MESH:D000086382), Fatty Liver Disease (MESH:D005234), inflammation (MESH:D007249), MASLD (MESH:D008107), lipid dyshomeostasis (MESH:D011017), PCOS (MESH:D011085), immune dysregulation (OMIM:614878), cardiometabolic diseases (MESH:D024821), liver injury (MESH:D017093)
- **Chemicals:** ethanol (MESH:D000431), RC (-), empagliflozin (MESH:C570240), GDCA (MESH:D006002), propionate (MESH:D011422), lipid (MESH:D008055), 5-methylcytosine (MESH:D044503), alcohol (MESH:D000438), Catechin gallate (MESH:C417939), bile acids (MESH:D001647), SCFAs (MESH:D005232)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606]
- **Mutations:** rs738409, rs9939609, rs17817449, rs2896019
- **Cell lines:** HepG2 — Homo sapiens (Human), Hepatoblastoma, Cancer cell line (CVCL_0027)

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Source: https://tomesphere.com/paper/PMC13025835