Research Progress on Anticancer Mechanism of Ginsenoside Regulating Tumor Microenvironment

TL;DR

This paper reviews how ginsenoside, a compound from ginseng, may help treat cancer by targeting the tumor microenvironment.

Contribution

The paper provides a new theoretical basis for using ginsenoside in cancer treatment by focusing on its effects on the tumor microenvironment.

Findings

Ginsenoside shows potential in overcoming chemotherapy limitations by targeting the tumor microenvironment.

Regulation of the tumor microenvironment by ginsenoside could lead to reduced tumor growth and improved treatment outcomes.

Ginsenoside's role in the tumor microenvironment highlights its potential as a novel therapeutic target.

Abstract

Cancer is currently one of the most significant health threats facing humanity in general. The clinical treatment of cancer is constrained by the current development of chemotherapy drug resistance, poor pharmacokinetics, off-target toxicity, and insufficient intratumoral accumulation. Although surgery combined with chemotherapy is now maturely used in clinical practice, the results are unsatisfactory, and the incidence and mortality of cancer continue to increase year by year with high side effects from treatment. Therefore, it is important to find more effective therapeutic targets against cancer. Alterations in the tumor microenvironment can lead to cellular gene mutations, which are an important cause of tumorigenesis, and therapeutic interventions targeting the tumor microenvironment have been one of the most interesting research areas in the oncology community in recent years. Ginseng is rich in antitumor-active ingredients and is used in the treatment of many cancer diseases. Ginsenoside is one of the main active components of ginseng. This paper reviews the antitumor mechanism of action of ginsenoside through regulating the tumor microenvironment, emphasizing the key role of ginsenoside in the tumor microenvironment and providing a new target and theoretical basis for ginsenoside in the treatment of cancer.

Figures