Roles of DNA Damage Response Pathway in the Regulation of the Nuclear Envelope

TL;DR

This paper reviews how DNA damage response pathways, especially the ATR kinase, regulate the nuclear envelope.

Contribution

The paper highlights ATR's novel role in linking DNA damage to nuclear envelope regulation.

Findings

NE rupture can cause DNA damage and is linked to DDR pathways.

ATR kinase is a key regulator in DNA damage-induced NE rupture.

DDR pathways play a central role in maintaining NE integrity.

Abstract

The nuclear envelope (NE) functions as a barrier between the cytoplasm and nucleus. Over the past decade, NE has revealed unexpectedly divergent structural alterations. NE rupture triggers the uncontrollable exchange of macromolecules across the NE and potentially causes DNA damage. Conversely, a recent study demonstrated that DNA damage induces NE rupture and that one of the major kinases in the DNA damage response (DDR) pathway, ataxia telangiectasia and Rad3-related protein, ATR, is a key molecule in these events. Here, we review the role of the DDR pathway in NE regulation, with a focus mainly on ATR.

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