# Cascade Valorisation of Lemon Processing Residues (Part II): Integrated Biorefinery Design, Circular Economy, and Techno-Economic Feasibility

**Authors:** Jimmy Núñez-Pérez, Jhomaira L. Burbano-García, Rosario Espín-Valladares, Marco V. Lara-Fiallos, Juan Carlos DelaVega-Quintero, Marcelo Cevallos-Vallejos, José-Manuel Pais-Chanfrau

PMC · DOI: 10.3390/foods15061041 · 2026-03-16

## TL;DR

This paper reviews the feasibility of using lemon processing waste in biorefineries to produce valuable products and energy, showing it can be economically and environmentally beneficial at large scales.

## Contribution

The paper provides a comprehensive techno-economic and environmental analysis of integrated lemon biorefineries, highlighting their viability and critical success factors.

## Key findings

- Cascade biorefineries can generate USD 400–650 per tonne of dry peel by recovering multiple products.
- Industrial-scale biorefineries (100,000+ tonnes/year) can achieve internal rates of return exceeding 18%.
- Greenhouse gas emissions can be reduced by 60–85% compared to conventional disposal methods.

## Abstract

This review examines the implementation dimensions of integrated lemon biorefinery systems, including cascade valorisation design, circular-economy integration, life-cycle assessment, techno-economic feasibility, and regulatory frameworks. Bibliometric analysis of Web of Science data (2015–2025) reveals exponential growth in citrus-biorefinery research, with lemon representing a burgeoning subset. Techno-economic assessments indicate that cascade biorefineries recovering essential oils, pectin, polyphenols, nanocellulose, and bioenergy can achieve cumulative revenues of USD 400–650 per tonne of dry peel. Whilst small-scale units (<500 tonnes per year) struggle to achieve viability, industrial simulations demonstrate Internal Rates of Return exceeding 18% at processing scales above 100,000 tonnes annually (2025 basis). Life-cycle assessments confirm environmental benefits, with greenhouse gas reductions of 60–85% relative to conventional disposal. Critical success factors include adopting green extraction technologies to preserve bioactive integrity and mitigating D-limonene inhibition in downstream anaerobic digestion. These findings establish essential oil extraction and pectin recovery as commercially mature technologies, whilst integrated multi-product lemon biorefineries remain economically promising based on techno-economic modelling and pilot-scale demonstrations, provided regulatory hurdles are effectively navigated.

## Linked entities

- **Chemicals:** D-limonene (PubChem CID 440917)

## Full-text entities

- **Chemicals:** D-limonene (MESH:D000077222), greenhouse gas (MESH:D000074382), essential oil (MESH:D009822), polyphenols (MESH:D059808), nanocellulose (-), pectin (MESH:D010368)
- **Species:** Citrus (genus) [taxon 2706], Citrus x limon (lemon, species) [taxon 2708]

## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13025514/full.md

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Source: https://tomesphere.com/paper/PMC13025514