PSMB8 as a Core Target Mediating the Anti-Hepatocellular Carci-Noma Activity of Lingonberry (Vaccinium vitis-idaea L.) Extract in HepG2 Cells
Liangyu Zhu, Zhi Zhang, Yandong Zhang, Dianwen Wei, Zhenyu Wang, Liping Zhou
TL;DR
Lingonberry extract shows anti-cancer effects in liver cancer cells by targeting PSMB8, offering a potential new treatment approach.
Contribution
Identifies PSMB8 as a core target mediating the anti-HCC activity of Lingonberry extract.
Findings
PSMB8 was identified as a core regulatory gene in HepG2 cells treated with Lingonberry extract.
Downregulating PSMB8 induces late apoptosis in HepG2 cells.
Lingonberry extract significantly reduces PSMB8 protein expression.
Abstract
Hepatocellular carcinoma (HCC) is a highly malignant tumour with a poor prognosis and few effective treatment options. Development of resistance to conventional therapies and occurrence of severe side effects highlight the urgent need for novel, low-toxicity interventions. Natural products are promising candidates for HCC drug development thanks to their multi-target activity and favourable safety profiles. Previous studies reported that Lingonberry extract, a bioactive natural product, inhibits proliferation of HepG2 cells. However, the key molecular targets and underlying anticancer mechanisms remain unclear. In this study, we analysed gene chip data from Lingonberry extract-treated HepG2 tumour-bearing mice using bioinformatics tools, employing a cross-species, multi-level screening strategy to identify PSMB8 as the core regulatory gene. In vitro functional validations (Western…
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Taxonomy
TopicsBioactive Natural Diterpenoids Research · Bioactive natural compounds · Piperaceae Chemical and Biological Studies