Injectable Thermosensitive Composite Hydrogels for Sustained Nanoparticle Delivery and Enhanced Wound Healing
Yiting Qiu, Zhiyun Cheng, Meiyan Liu, Dagui Zhang, Xia Gao, Longxiang Feng, Xianxiang Xu, Haoyang You, Xunxun Wu, Yong Diao
TL;DR
A new injectable hydrogel was developed to deliver nanoparticles for faster wound healing by reducing oxidative stress and promoting tissue regeneration.
Contribution
A thermosensitive hydrogel was created for sustained delivery of sinomenine–gallic acid nanoparticles to enhance wound healing.
Findings
The hydrogel enables sustained SGNP release for up to 24 hours and shows good hemocompatibility.
In vitro tests showed improved keratinocyte migration and proliferation.
In mice, the hydrogel accelerated wound closure and improved tissue regeneration.
Abstract
Wound healing is frequently compromised by excessive oxidative stress, prolonged inflammation, and inadequate tissue regenerative capacity. To address these challenges, a thermosensitive and injectable composite hydrogel based on Pluronic F127 (F127), phosphatidylcholine (PC), and L-lysine (Lys) was developed for the sustained delivery of sinomenine–gallic acid nanoparticles (SGNPs) and the acceleration of wound repair. The hydrogel undergoes a rapid sol–gel transition at physiological temperatures through physical interactions, enabling excellent injectability and in situ gelation. The optimized composite hydrogel exhibited improved mechanical properties, enhanced structural stability, and a uniform porous microarchitecture. The F127−Lys−PCF127−Lys−PC@SGNPs hydrogel showed superior overall stability and hemocompatibility while enabling the sustained release of SGNPs for up to 24 h.…
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Taxonomy
TopicsWound Healing and Treatments · Hydrogels: synthesis, properties, applications · Graphene and Nanomaterials Applications