Current Understanding of SIRT7 Function and Its Emerging Roles in the Central Nervous System

TL;DR

This review summarizes the role of SIRT7 in the brain, focusing on its impact on neuronal health and disease.

Contribution

The paper highlights new insights into SIRT7's emerging roles in the central nervous system and its potential in neurological diseases.

Findings

SIRT7 is involved in chromatin regulation and cellular stress response in the nucleolus.

SIRT7 contributes to DNA repair and metabolic regulation, linking it to cancer and metabolic disorders.

Emerging evidence suggests SIRT7's role in neuronal homeostasis and neuroinflammation in the CNS.

Abstract

SIRT7is an NAD+-dependent deacetylase predominantly localized in the nucleolus, where it plays important roles in chromatin regulation, transcriptional control, and cellular stress response. Accumulating evidence has revealed that SIRT7 participates in multiple molecular processes, including ribosomal RNA transcription, histone modification, DNA damage repair, metabolic regulation, and inflammatory signaling pathways. Through these mechanisms, SIRT7 contributes to the pathogenesis of various human diseases, particularly cancer and metabolic disorders. In recent years, emerging studies have begun to uncover the roles of SIRT7 in the central nervous system (CNS). Although research in this area remains limited, available evidence suggests that SIRT7 may be involved in neuronal homeostasis, glial function, neuroinflammation, and responses to brain injury. Furthermore, dysregulation of SIRT7 has been implicated in CNS-related pathologies. In this review, we summarize the understanding of SIRT7 molecular mechanisms and its implications in human disease, with special emphasis on its emerging roles in the CNS. We also address unresolved questions and propose future research directions to facilitate a deeper understanding of SIRT7 in neurological physiology and pathology.

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