# Subject-Independent Depression Recognition from EEG Using an Improved Bidirectional LSTM with Dynamic Vector Routing

**Authors:** Ziqi Ji, Kunye Liu, Weikai Ma, Xiaolin Ning, Yang Gao

PMC · DOI: 10.3390/bioengineering13030358 · Bioengineering · 2026-03-19

## TL;DR

This paper introduces a new improved BiLSTM model for recognizing depression from EEG data, achieving high accuracy and better generalization.

## Contribution

The novel contribution is an improved BiLSTM with dynamic vector routing for subject-independent depression recognition from EEG.

## Key findings

- The proposed model achieves 84.8% accuracy and an AUC of 0.899 on the MODMA dataset.
- Multi-frequency input improves classification performance compared to single frequency bands.

## Abstract

Electroencephalography (EEG) has become an increasingly important tool in depression research due to its ability to capture objective neurophysiological abnormalities associated with depressive disorders, offering high temporal resolution, non-invasiveness, and cost-effectiveness.However, existing methods often fail to fully exploit the multi-domain information in EEG signals, resulting in limited model generalization capabilities. This paper proposes an improved bidirectional long short-term memory (BiLSTM) model that segments continuous EEG into non-overlapping 2-s epochs and learns end-to-end from multi-channel temporal sequences. After band-pass filtering and resampling, each epoch is represented as a channel–time matrix X∈RC×T (with C = 128) and processed by a BiLSTM encoder followed by a dynamic-routing encapsulated-vector classifier. On the MODMA dataset under subject-independent five-fold cross-validation, the proposed method outperforms a set of reproduced representative baselines (SVM, EEGNet, InceptionNet, Self-attention-CNN and CNN–LSTM) and achieves 84.8% accuracy with an AUC of 0.899. We further discuss recent contemporary directions (e.g., attention/Transformer-based and emotion-aware expert models) and clarify the scope of our empirical comparisons. Furthermore, experiments comparing different frequency bands and band combinations indicate that joint multi-frequency input can enhance classification performance. This study provides an effective multi-domain fusion approach for the automatic diagnosis of depression based on EEG.

## Linked entities

- **Diseases:** depression (MONDO:0002050)

## Full-text entities

- **Diseases:** Depression (MESH:D003866)

## Full text

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## Figures

8 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13024425/full.md

## References

53 references — full list in the complete paper: https://tomesphere.com/paper/PMC13024425/full.md

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Source: https://tomesphere.com/paper/PMC13024425