# Selected Nutraceuticals in Metabolic Syndrome: Molecular Mechanisms and Clinical Implications

**Authors:** Josè Starvaggi, Carla Di Chio, Fabiola De Luca, Santo Previti, Maria Zappalà, Roberta Ettari

PMC · DOI: 10.3390/biomedicines14030646 · Biomedicines · 2026-03-12

## TL;DR

This review explores how certain natural compounds called nutraceuticals may help manage metabolic syndrome and related conditions like cardiovascular disease and diabetes.

## Contribution

The paper provides a detailed analysis of selected nutraceuticals and their potential role in addressing metabolic syndrome.

## Key findings

- Nutraceuticals show anti-inflammatory, antioxidant, and antitumor properties.
- They may help prevent and manage cardiovascular diseases linked to metabolic syndrome.
- Nutraceuticals could offer new strategies for treating metabolic disturbances.

## Abstract

In recent years, there has been a growing scientific and clinical interest in nutraceuticals, bioactive compounds derived from natural sources such as plants, fruits and cereals. These substances have gained prominence due to their diverse pharmacological properties, particularly their anti-inflammatory, antioxidant and antitumor activities. In addition, scientific evidence supports their beneficial role in the prevention and management of cardiovascular diseases, which represent the principal focus of the present review. This review provides a comprehensive and detailed analysis of selected nutraceuticals related to the metabolic syndrome, a multifactorial pathological condition characterized by a cluster of metabolic disturbances that collectively increase the risk of developing cardiovascular disease and type 2 diabetes. The metabolic syndrome is typically defined by the presence of abdominal obesity, insulin resistance, hypertension and dyslipidemia, which includes elevated plasma triglyceride levels and decreased concentrations of high-density lipoprotein (HDL) cholesterol. Given the global importance and prevalence of metabolic syndrome, identifying new strategies to treat these disorders, such as the use of nutraceuticals, has become a central focus of biomedical research.

## Linked entities

- **Diseases:** metabolic syndrome (MONDO:0000816), cardiovascular disease (MONDO:0004995), type 2 diabetes (MONDO:0005148)

## Full-text entities

- **Diseases:** Metabolic Syndrome (MESH:D024821), hypertension (MESH:D006973), inflammatory (MESH:D007249), abdominal obesity (MESH:D056128), cardiovascular disease (MESH:D002318), insulin resistance (MESH:D007333), dyslipidemia (MESH:D050171), type 2 diabetes (MESH:D003924)
- **Chemicals:** triglyceride (MESH:D014280), cholesterol (MESH:D002784)

## Full text

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## Figures

24 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13024294/full.md

## References

160 references — full list in the complete paper: https://tomesphere.com/paper/PMC13024294/full.md

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Source: https://tomesphere.com/paper/PMC13024294