# Impact of Antioxidant-Rich Whole Foods or Supplements on Skin Health: A Systematic Review and Meta-Analysis of Preclinical and Clinical Studies

## TL;DR

This study reviews and analyzes how antioxidant-rich foods or supplements affect skin health based on preclinical and clinical research.

## Contribution

The paper provides a systematic review and meta-analysis of antioxidant effects on skin health, combining preclinical and clinical findings.

## Key findings

- Antioxidant interventions improved skin hydration and reduced trans-epidermal water loss in preclinical studies.
- Clinical studies showed similar improvements in skin hydration and reduced TEWL with antioxidant use.
- Antioxidants also reduced dermatitis scores and improved skin density and quality of life metrics.

## Abstract

Background: Antioxidant supplements have been reported to confer benefits for skin health; however, these effects remain inconclusive and lack systematic evaluation. Methods: This systematic review and meta-analysis assessed the impact of antioxidant-rich whole foods or supplements on various skin health outcomes by compiling data from five databases, including 94 eligible preclinical and clinical studies. Results: The intervention improved overall skin health in preclinical studies, as evidenced by increased skin hydration (Hedges’ g = 1.75, 95% CI [1.31; 2.20]) and hyaluronic acid, decreased trans-epidermal water loss (TEWL) (Hedges’ g = −2.15, 95% CI [−3.17; −1.13]), epidermal thickness (Hedges’ g = −2.59, 95% CI [−3.28; −1.89]), wrinkle formation, and dermatitis scores, alongside changes in inflammatory cytokines and Immunoglobulin E (IgE) levels. As for clinical studies, the intervention increased skin hydration (MD = 2.12, 95% CI [1.02; 3.21]) while decreased TEWL (MD = −0.68, 95% CI [−1.21; −0.16]). Additionally, changes in skin density, epidermal thickness, minimal erythema dose (MED), SCORing Atopic Dermatitis (SCORAD) and the Dermatitis Life Quality Index (DLQI) further support overall improvements for skin health. Conclusions: Antioxidant-rich whole foods or supplements intake improved overall skin health and skin disorder conditions. The magnitude of benefit may vary according to the type of antioxidant and the duration of intervention.