# A Cloud-Aware Scalable Architecture for Distributed Edge-Enabled BCI Biosensor System

**Authors:** Sayantan Ghosh, Raghavan Bhuvanakantham, Padmanabhan Sindhujaa, Purushothaman Bhuvana Harishita, Anand Mohan, Balázs Gulyás, Domokos Máthé, Parasuraman Padmanabhan

PMC · DOI: 10.3390/bios16030157 · Biosensors · 2026-03-13

## TL;DR

This paper introduces a scalable, cloud-aware biosensor system for BCI that reduces latency and integrates edge computing with cloud infrastructure.

## Contribution

A novel cloud-aware cognitive grid architecture for BCI biosensors with a validated physical prototype and tiered data pipeline.

## Key findings

- Edge-level inference achieved with bounded latency using TinyML on RP2040 microcontroller.
- Cloud-assisted analytics showed variable delays but packet loss remained below 5%.
- Hybrid deployment strategies enabled cost-efficient validation while maintaining system fidelity.

## Abstract

BCI biosensors enable continuous monitoring of neural activity, but existing systems face challenges in scalability, latency, and reliable integration with cloud infrastructure. This work presents a cloud-aware, real-time cognitive grid architecture for multimodal BCI biosensors, validated at the system level through a full physical prototype. The system integrates the BioAmp EXG Pill for signal acquisition with an RP2040 microcontroller for local preprocessing using edge-resident TinyML deployment for on-device feature/inference feasibility coupled with environmental context sensors to augment signal context for downstream analytics talking to the external world via Wi-Fi/4G connectivity. A tiered data pipeline was implemented: SD card buffering for raw signals, Redis for near-real-time streaming, PostgreSQL for structured analytics, and AWS S3 with Glacier for long-term archival. End-to-end validation demonstrated consistent edge-level inference with bounded latency, while cloud-assisted telemetry and analytics exhibited variable transmission and processing delays consistent with cellular connectivity and serverless execution characteristics; packet loss remained below 5%. Visualization was achieved through Python 3.10 using Matplotlib GUI, Grafana 10.2.3 dashboards, and on-device LCD displays. Hybrid deployment strategies—local development, simulated cloud testing, and limited cloud usage for benchmark capture—enabled cost-efficient validation while preserving architectural fidelity and latency observability. The results establish a scalable, modular, and energy-efficient biosensor framework, providing a foundation for advanced analytics and translational BCI applications to be explored in subsequent work, with explicit consideration of both edge-resident TinyML inference and cloud-based machine learning workflows.

## Full-text entities

- **Genes:** ASCC1 (activating signal cointegrator 1 complex subunit 1) [NCBI Gene 51008] {aka ASC1p50, CGI-18, SMABF2, p50}
- **Diseases:** injury to (MESH:D014947), fatigue (MESH:D005221), pain (MESH:D010146), ML (MESH:C537366)
- **Chemicals:** RP2040 (-), benzene (MESH:D001554), VOCs (MESH:D055549), alcohol (MESH:D000438), ammonia (MESH:D000641)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** RP2040 — Homo sapiens (Human), Transformed cell line (CVCL_K802)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC13024191/full.md

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13024191/full.md

## References

99 references — full list in the complete paper: https://tomesphere.com/paper/PMC13024191/full.md

---
Source: https://tomesphere.com/paper/PMC13024191