# Neural Oscillatory and Network Signatures of Age-Related Cognitive Decline Under Motor-Cognitive Dual-Task Conditions

## TL;DR

This study explores how aging affects brain function during combined motor and cognitive tasks, revealing differences in neural activity and performance between younger and older adults.

## Contribution

The study introduces a novel motor-cognitive dual-task paradigm to detect early signs of age-related cognitive decline using multimodal neural and behavioral data.

## Key findings

- Older adults showed significantly worse performance in dual-task accuracy, reaction time, and composite scores compared to younger adults.
- Older adults exhibited localized gamma-band power increases in posterior-temporal regions post-task, while younger adults showed widespread multi-band power modulation.
- Younger adults demonstrated enhanced brain network connectivity and organization post-task, whereas older adults showed network rigidity and localized compensatory patterns.

## Abstract

Background: Against the backdrop of global population aging, understanding the mechanisms of age-related cognitive decline has become crucial for improving the health and quality of life in older adults. Methods: This study employed a multimodal approach to investigate the neural modulations induced by a motor cognitive dual task and their relationship with age-related decline. By integrating behavioral assessments, electroencephalography (EEG), and body composition analysis, we comprehensively evaluated performance and neural correlates in 19 younger and 18 older adults. Specifically, EEG analyses focused on comparing pre-task and post-task resting-state recordings to investigate the immediate impact of a single acute cognitive-motor dual-task session on neural oscillations and brain network organization. Results: Key findings include: (1) older adults exhibited significantly inferior performance in task accuracy, reaction time, and composite performance score compared to younger adults (p < 0.001); (2) neural oscillatory analysis of resting-state data revealed a localized increase in gamma-band power at posterior-temporal sites (PO4/T6) in older adults following the dual-task, while younger adults exhibited widespread multi-band (delta to beta) power modulation across frontal, central, and temporal regions in younger adults; (3) brain network analysis demonstrated synergistic enhancement of multi-band (Theta, Alpha, Beta, Gamma) connectivity and optimized topological organization in younger adults post-task, contrasting with network rigidity and localized compensatory patterns in older adults; (4) correlation analyses indicated significant associations between dual-task performance and MoCA-B scores in older adults (r = 0.861, p < 0.001). Conclusions: This study innovatively elucidates the neurophysiological characteristics of brain aging. The motor-cognitive dual-task paradigm proves to be a sensitive tool for capturing early cognitive changes, holding significant promise for clinical screening.