# Obstructive Sleep Apnea and Coronary Artery Disease: An Overlooked Cardiovascular Risk Factor

## TL;DR

This paper reviews how obstructive sleep apnea worsens heart disease and highlights the need for better screening and treatment strategies.

## Contribution

The paper synthesizes current evidence on OSA's role in CAD and emphasizes the importance of systematic screening and adherence to therapy.

## Key findings

- OSA increases CAD risk through mechanisms like hypoxia and inflammation.
- CPAP therapy improves some outcomes but lacks strong evidence for major cardiovascular benefits.
- Observational studies suggest better survival with CPAP adherence.

## Abstract

Obstructive sleep apnea syndrome (OSA) is increasingly recognized as a common and clinically relevant comorbidity in coronary artery disease (CAD). Epidemiological studies demonstrate that OSA is highly prevalent among patients with CAD and independently increases the risk of myocardial infarction, accelerated atherosclerosis, and recurrent adverse events. The pathophysiological mechanisms underlying this association include intermittent hypoxia, sympathetic overactivation, oxidative stress, endothelial dysfunction, systemic inflammation, metabolic dysregulation, and pro-prothrombotic changes. These processes converge to promote coronary plaque formation, instability, and ischemia. Clinical evidence indicates that OSA contributes to silent nocturnal ischemia, higher rates of acute coronary syndromes, restenosis after percutaneous coronary intervention, and worse prognosis following myocardial infarction or surgical revascularization. Continuous positive airway pressure (CPAP) therapy improves blood pressure, endothelial function, and surrogate markers of ischemia, but large randomized trials have yielded neutral results on major cardiovascular events, largely due to suboptimal adherence. However, observational studies, however, suggest improved survival in patients who are adherent to CPAP therapy. Lifestyle interventions, particularly weight reduction, remain essential adjunctive strategies. This review synthesizes current evidence, evaluates therapeutic implications, and highlights the need for systematic OSA screening in CAD populations. Future research should focus on patient phenotyping, treatment adherence, and integrated care models to improve cardiovascular outcomes.