# Scale-Free Neurodynamics as Functional Fingerprint of Brain Regions

## TL;DR

This study shows that brain regions have unique electrical activity patterns, which could help classify and understand how the brain is organized.

## Contribution

The paper introduces scale-free neurodynamics as a novel functional fingerprint for distinguishing brain regions.

## Key findings

- Scale-free activity was observed in two frequency ranges (0.5–4 Hz and 33–80 Hz).
- High-frequency power-law exponents differed significantly between cortical and subcortical areas.
- Scale-free neurodynamics may serve as a functional fingerprint for brain region classification.

## Abstract

This study investigates the ongoing electrical activity of local neural networks—referred to as neurodynamics—across 37 anatomically defined brain regions. We analyzed stereotactic intracranial EEG (sEEG) recordings from 106 subjects during wakeful rest, focusing on scale-free (power-law) properties to determine whether distinct brain regions exhibit unique neurodynamic signatures. Results revealed a power-law regime in two frequency ranges (approximately 0.5–4 Hz and 33–80 Hz). Notably, the power-law exponent (slope) in the high-frequency band differed significantly between cortical and subcortical areas (p < 0.01). These findings suggest that local neurodynamics, as reflected in scale-free characteristics, may serve as a functional “fingerprint” for brain region classification. This approach may contribute to functional brain parcellation efforts and offer new insights into the intrinsic organization of neuronal networks as revealed by resting-state activity analysis.