# Mitochondrial Stress in Helicobacter pylori Infection and Associated Malignancies: A Review

## TL;DR

This review explores how mitochondrial stress contributes to Helicobacter pylori infection and related cancers like gastric cancer and MALT lymphoma.

## Contribution

The paper highlights the under-researched role of mitochondrial stress in H. pylori-associated malignancies.

## Key findings

- Mitochondrial stress is a key factor in H. pylori infection and related cancers.
- Mitochondria regulate cellular processes and influence cancer progression in these diseases.
- The review summarizes current knowledge on mitochondrial alterations in H. pylori-related malignancies.

## Abstract

Helicobacter pylori (H. pylori) infection is one of the most common bacterial infections worldwide. Its role in infection-associated cancers, such as gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma is well known. However, mitochondrial alterations in these malignancies are less documented. Mitochondria are key organelles, maintaining cellular homeostasis under normal and pathological conditions. They regulate complex cellular processes and play a key role in carcinogenesis and cancer progression in H. pylori-associated malignancies. This review summarizes the role of mitochondrial stress in H. pylori infection, gastric cancer, and MALT lymphoma.