# Breast Cancer in Relation to Dairy Product Consumption: A Review of Current Findings and Potential Mechanisms

**Authors:** Dilara Nur Kaplan, Nevin Sanlier

PMC · DOI: 10.1007/s13668-026-00753-5 · Current Nutrition Reports · 2026-03-26

## TL;DR

This paper reviews how dairy product consumption may be linked to breast cancer, highlighting mixed findings and potential mechanisms.

## Contribution

The paper provides a comprehensive review of current findings and mechanisms linking dairy consumption to breast cancer.

## Key findings

- Dairy products may have both protective and harmful effects on breast cancer through various pathways.
- Milk proteins like α-casein show potential protective effects against breast cancer.
- Carcinogenic compounds in dairy products may contribute to cancer risk, requiring further study.

## Abstract

Breast cancer is the most frequently diagnosed cancer in women globally, and the widespread consumption of dairy products makes this association important for public health. Epidemiological studies have shown mixed results, with some reporting inverse or positive associations and others finding no clear link. The impact may differ depending on the type of dairy product, lifetime consumption patterns, and tumor subtype. This review evaluates proposed mechanisms of action, relevant nutritional components, and potential effects of dairy product consumption in the context of breast cancer.

Milk and dairy products have been associated with both promotive and inhibitory effects on breast cancer through diverse signaling pathways. Outcomes appear to be shaped by genetic background, tumor subtype, and the specific components consumed. Certain milk proteins, such as α-casein, have demonstrated protective potential and may contribute to new therapeutic strategies. In contrast, the possible presence of carcinogenic compounds in dairy products highlights the need for further investigation to clarify these associations and inform dietary recommendations.

The relationship between dairy and breast cancer is multifaceted, requiring personalized dietary recommendations and further investigation of underlying mechanisms. Inconsistencies in current findings emphasize the need for standardized research approaches that consider dietary patterns, genetic predisposition, and life-stage–specific consumption. Future studies should also address fermented versus unfermented products, fat content, and dose–response relationships to better understand these associations and inform dietary guidelines.

## Linked entities

- **Diseases:** breast cancer (MONDO:0004989)

## Full-text entities

- **Genes:** CXCL8 (C-X-C motif chemokine ligand 8) [NCBI Gene 280828] {aka IL-8, IL8}, DNMT1 (DNA methyltransferase 1) [NCBI Gene 1786] {aka ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT}, CSN1S1 (casein alpha s1) [NCBI Gene 282208] {aka CSN1}, ESR1 (estrogen receptor 1) [NCBI Gene 407238], CDKN1A (cyclin dependent kinase inhibitor 1A) [NCBI Gene 513497] {aka CIP1, SDI1, WAF1, p21}, TGFA (transforming growth factor alpha) [NCBI Gene 7039] {aka TFGA}, PGR (progesterone receptor) [NCBI Gene 5241] {aka NR3C3, PR}, CSN1S2 (casein alpha-S2) [NCBI Gene 282209], TNF (tumor necrosis factor) [NCBI Gene 280943] {aka TNF-a, TNF-alpha, TNFa}, CSF2 (colony stimulating factor 2) [NCBI Gene 281095] {aka CSF, GM-CSF, GMCSF}, GH1 (growth hormone 1) [NCBI Gene 2688] {aka GH, GH-N, GHB5, GHN, IGHD1A, IGHD1B}, RHEB (Ras homolog, mTORC1 binding) [NCBI Gene 6009] {aka RHEB2}, EP300 (EP300 lysine acetyltransferase) [NCBI Gene 2033] {aka KAT3B, MKHK2, RSTS2, p300}, CDKN2D (cyclin dependent kinase inhibitor 2D) [NCBI Gene 510244], SERPINE1 (serpin family E member 1) [NCBI Gene 5054] {aka PAI, PAI-1, PAI1, PLANH1}, ZHX2 (zinc fingers and homeoboxes 2) [NCBI Gene 22882] {aka AFR1, RAF}, CD44 (CD44 molecule (IN blood group)) [NCBI Gene 960] {aka CDW44, CSPG8, ECM-III, ECMR-III, H-CAM, HCELL}, CDKN1B (cyclin dependent kinase inhibitor 1B) [NCBI Gene 512613], CAT (catalase) [NCBI Gene 531682], EREG (epiregulin) [NCBI Gene 2069] {aka EPR, ER, Ep}, ELK1 (ETS transcription factor ELK1) [NCBI Gene 2002], PAEP (progestagen-associated endometrial protein) [NCBI Gene 280838] {aka BLG, LGB}, ORC1 (origin recognition complex subunit 1) [NCBI Gene 513523] {aka ORC1L}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, MIR215 (microRNA 215) [NCBI Gene 406997] {aka MIRN215, miRNA215, mir-215}, PLAUR (plasminogen activator, urokinase receptor) [NCBI Gene 5329] {aka CD87, U-PAR, UPAR, URKR}, AKT1 (AKT serine/threonine kinase 1) [NCBI Gene 207] {aka AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA}, ESR1 (estrogen receptor 1) [NCBI Gene 2099] {aka ER, ESR, ESRA, ESTRR, Era, NR3A1}, BCL2 (BCL2 apoptosis regulator) [NCBI Gene 596] {aka Bcl-2, PPP1R50}, CCNA1 (cyclin A1) [NCBI Gene 521939], CSN3 (casein kappa) [NCBI Gene 281728] {aka CSN10, CSN3K, CSNK}, ERBB2 (erb-b2 receptor tyrosine kinase 2) [NCBI Gene 2064] {aka CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19}, INS (insulin) [NCBI Gene 280829], CCNE1 (cyclin E1) [NCBI Gene 533526], BAX (BCL2 associated X, apoptosis regulator) [NCBI Gene 280730], FTO (FTO alpha-ketoglutarate dependent dioxygenase) [NCBI Gene 618622], LALBA (lactalbumin alpha) [NCBI Gene 281894] {aka a-LACTA, alfaLA}, MIR215 (microRNA mir-215) [NCBI Gene 791015] {aka MIRN215, bta-mir-215, mir-215}, TLR4 (toll like receptor 4) [NCBI Gene 7099] {aka ARMD10, CD284, TLR-4, TOLL}, STAT3 (signal transducer and activator of transcription 3) [NCBI Gene 6774] {aka ADMIO, ADMIO1, APRF, HIES}, LTF (lactotransferrin) [NCBI Gene 280846] {aka Lf}, PTEN (phosphatase and tensin homolog) [NCBI Gene 5728] {aka 10q23del, BZS, CWS1, DEC, GLM2, MHAM}, IL10 (interleukin 10) [NCBI Gene 3586] {aka CSIF, GVHDS, IL-10, IL10A, TGIF}, IGF1 (insulin like growth factor 1) [NCBI Gene 3479] {aka IGF, IGF-I, IGFI, MGF}, PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) [NCBI Gene 282306], CREBBP (CREB binding lysine acetyltransferase) [NCBI Gene 1387] {aka CBP, KAT3A, MKHK1, RSTS, RSTS1}, CSN2 (casein beta) [NCBI Gene 281099], PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta) [NCBI Gene 5291] {aka P110BETA, PI3K, PI3KBETA, PIK3C1}, HIF1A (hypoxia inducible factor 1 subunit alpha) [NCBI Gene 3091] {aka HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1}, JUN (Jun proto-oncogene, AP-1 transcription factor subunit) [NCBI Gene 3725] {aka AP-1, AP1, c-Jun, cJUN, p39}, IGF1 (insulin like growth factor 1) [NCBI Gene 281239] {aka IGF-1, IGF-I}, IFNG (interferon gamma) [NCBI Gene 3458] {aka IFG, IFI, IMD69}, TGFB1 (transforming growth factor beta 1) [NCBI Gene 7040] {aka CAEND1, CED, DPD1, IBDIMDE, LAP, TGF-beta1}, BRCA1 (BRCA1 DNA repair associated) [NCBI Gene 353120], STAT1 (signal transducer and activator of transcription 1) [NCBI Gene 6772] {aka CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91}, BAX (BCL2 associated X, apoptosis regulator) [NCBI Gene 581] {aka BCL2L4}, AKT1 (AKT serine/threonine kinase 1) [NCBI Gene 280991] {aka AKT}, TSC2 (TSC complex subunit 2) [NCBI Gene 7249] {aka LAM, PPP1R160, TSC4}, LOC517016 (interleukin 6 (interferon, beta 2)) [NCBI Gene 517016] {aka IF1DA6}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** stroke (MESH:D020521), Cancer (MESH:D009369), obesity (MESH:D009765), TNBC (MESH:D064726), type II diabetes (MESH:D003924), deaths (MESH:D003643), Carcinogenesis (MESH:D063646), metastasis (MESH:D009362), bladder cancer (MESH:D001749), necrosis (MESH:D009336), stomach cancer (MESH:D013274), toxicity (MESH:D064420), Breast Cancer (MESH:D001943), cardiovascular diseases (MESH:D002318), hypoxic (MESH:D002534), inflammatory (MESH:D007249), carcinogenic (MESH:D011230), colorectal cancer (MESH:D015179)
- **Chemicals:** PUFA polyunsaturated fatty acids (MESH:D005231), lactose (MESH:D007785), Aflatoxin M1 (MESH:D016607), riboflavin (MESH:D012256), reactive oxygen species (MESH:D017382), A, B1, B2, C, and D (-), MUFA monounsaturated fatty acids (MESH:D005229), magnesium (MESH:D008274), Calcium (MESH:D002118), amino acids (MESH:D000596), bile acids (MESH:D001647), methionine (MESH:D008715), dietary fat (MESH:D004041), carbohydrates (MESH:D002241), arginine (MESH:D001120), Vitamin D (MESH:D014807), 1,25-(OH)2D3 (MESH:D002117), vitamin B12 (MESH:D014805), alcohol (MESH:D000438), iron (MESH:D007501), tryptophan (MESH:D014364), lipid (MESH:D008055), butyrate (MESH:D002087), Bisphenol A (MESH:C006780), fat (MESH:D005223), tyrosine (MESH:D014443), potassium (MESH:D011188), vitamin B6 (MESH:D025101), free fatty acid (MESH:D005230), conjugated linoleic acid (MESH:D044243), aflatoxins (MESH:D000348)
- **Species:** Bos taurus (bovine, species) [taxon 9913], Rattus norvegicus (brown rat, species) [taxon 10116], Bacteria Latreille et al. 1825 (Bacteria stick insect, genus) [taxon 629395], Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** MDA-MB-468 — Homo sapiens (Human), Breast adenocarcinoma, Cancer cell line (CVCL_0419), MCF-7 — Homo sapiens (Human), Invasive breast carcinoma of no special type, Cancer cell line (CVCL_0031), SKBR3 — Homo sapiens (Human), Breast adenocarcinoma, Cancer cell line (CVCL_0033), T47D — Homo sapiens (Human), Invasive breast carcinoma of no special type, Cancer cell line (CVCL_0553), MDA-MB-231 — Homo sapiens (Human), Breast adenocarcinoma, Cancer cell line (CVCL_0062), MDA-MB-453 — Homo sapiens (Human), Breast adenocarcinoma, Cancer cell line (CVCL_0418)

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13021875/full.md

## References

5 references — full list in the complete paper: https://tomesphere.com/paper/PMC13021875/full.md

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Source: https://tomesphere.com/paper/PMC13021875