# Neuro-Oncology of Women (NOW): Special Considerations Regarding Management of Women of Reproductive Age with Glioma

**Authors:** Alexandra Simpson Farrukh, Terri Lynn Woodard, Jennifer L Hopp, Caitlyn Hull, Na Tosha Gatson

PMC · DOI: 10.1007/s11912-026-01748-9 · Current Oncology Reports · 2026-03-26

## TL;DR

This paper reviews specialized cancer care for women of reproductive age with gliomas, highlighting unique considerations like fertility and pregnancy planning.

## Contribution

The paper provides a streamlined guideline for managing glioma in women of reproductive age, addressing gaps in current clinical practices.

## Key findings

- Current management lacks a central resource, leading to inconsistent care for women with gliomas.
- Special considerations include fertility preservation, epilepsy management, and sexual well-being.
- Clinicians often fail to adhere to guidelines for neuro-oncology of women.

## Abstract

Cancer care for women is nuanced, and this is particularly true for neuro-oncology of women (NOW). A subset of women who require even more specialized care are those of reproductive age. The purpose of this review is to streamline guideline-directed care for women with gliomas, specifically those of childbearing potential.

No central resource for management of glioma in women exists, and previous studies show that clinicians do not always adhere to guideline-directed care of these patients and significant care gaps exist for NOW patients.

NOW patients have special considerations in their cancer care including but not limited to pregnancy planning, chemotherapy counseling, management of epilepsy, fertility, and sexual well-being.

## Linked entities

- **Diseases:** glioma (MONDO:0021042)

## Full-text entities

- **Genes:** VEGFA (vascular endothelial growth factor A) [NCBI Gene 7422] {aka L-VEGF, MVCD1, VEGF, VPF}, IDH1 (isocitrate dehydrogenase (NADP(+)) 1) [NCBI Gene 3417] {aka HEL-216, HEL-S-26, IDCD, IDH, IDP, IDPC}, CYP3A4 (cytochrome P450 family 3 subfamily A member 4) [NCBI Gene 1576] {aka CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4}
- **Diseases:** congenital malformation (OMIM:163000), neuroblastoma (MESH:D009447), effects (MESH:D065606), Glioma (MESH:D005910), POF (MESH:C564499), proteinuria (MESH:D011507), meningioma (MESH:D008579), POI (MESH:D016649), pre-eclampsia (MESH:D011225), autism-spectrum disorder (MESH:D000067877), leukemia (MESH:D007938), Cancers (MESH:D009369), genitopelvic pain/penetration disorder (MESH:D013001), death (MESH:D003643), Wilms tumor (MESH:D009396), brain necrosis (MESH:D001927), neural tube defects (MESH:D009436), glioblastoma (MESH:D005909), Epilepsy (MESH:D004827), ependymomas (MESH:D004806), lymphoma (MESH:D008223), hair loss (MESH:D000505), SD (MESH:D012735), Mental Disorders (MESH:D001523), IDH-MT (MESH:D016115), cervical cancer (MESH:D002583), ovarian toxicity (MESH:D010049), astrocytoma (MESH:D001254), Brain tumor (MESH:D001932), malformations (MESH:C564254), vasogenic edema (MESH:D001929), hypertension (MESH:D006973), hepatic or cardiac co-morbidities (MESH:D066126), leukopenia (MESH:D007970), breast and gynecologic cancers (MESH:D001943), toxicity (MESH:D064420), oligodendroglioma (MESH:D009837), neurodevelopmental sequalae (MESH:D008607), brain and spinal cord tumors (MESH:D013120), ASM (MESH:D012640), FP (MESH:D007246), fetal malformations (MESH:D000013), arousal and orgasmic disorders (MESH:D020018), thrombocytopenia (MESH:D013921), VTE (MESH:D054556), CNS tumors (MESH:D016543), medulloblastoma (MESH:D008527), epilepsy syndrome (MESH:D000073376), unintended pregnancy (MESH:D011254)
- **Chemicals:** Vorasidenib (MESH:C000716758), Antiseizure Medication (-), oxcarbazepine (MESH:D000078330), phenobarbital (MESH:D010634), folic acid (MESH:D005492), lamotrigine (MESH:D000077213), lacosamide (MESH:D000078334), Procarbazine (MESH:D011344), LMWH (MESH:D006495), TMZ (MESH:D000077204), Levetiracetam (MESH:D000077287), CCNU (MESH:D008130), Bevacizumab (MESH:D000068258), progesterone (MESH:D011374), Vincristine (MESH:D014750), heparin (MESH:D006493), cyclophosphamide (MESH:D003520), topiramate (MESH:D000077236), carbamazepine (MESH:D002220), phenytoin (MESH:D010672), etonogestrel (MESH:C044815), valproic acid (MESH:D014635), primidone (MESH:D011324), levonorgestrel (MESH:D016912)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

3 references — full list in the complete paper: https://tomesphere.com/paper/PMC13021733/full.md

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Source: https://tomesphere.com/paper/PMC13021733