# MotifPeeker: benchmarking epigenomic profiling methods using motifs

## TL;DR

MotifPeeker is a tool that evaluates epigenomic profiling methods by checking how well they detect transcription factor motifs.

## Contribution

It introduces a new benchmarking approach using motif enrichment in the absence of a gold standard.

## Key findings

- MotifPeeker provides an intuitive HTML report with minimal input from users.
- The tool is available on Bioconductor and GitHub with full documentation and a Docker image.

## Abstract

MotifPeeker benchmarks epigenomic profiling methods targeting transcription factors (TFs) where no ‘gold standard’ reference exists, using motif enrichment as a key metric. With minimal input, users can analyse their data in a single function and receive an intuitive HTML report.

MotifPeeker is available on Bioconductor (≥v3.21) at https://bioconductor.org/packages/MotifPeeker. The complete source code is available on GitHub at https://github.com/neurogenomics/MotifPeeker, with full documentation provided at https://neurogenomics.github.io/MotifPeeker. Additionally, the MotifPeeker Docker image is hosted on GitHub at https://github.com/neurogenomics/MotifPeeker/pkgs/container/motifpeeker.