# Prevalence of primary dysmenorrhea and its associated factors among adolescent girls in a rural setting of Pakistan

**Authors:** Naureen Rehman, Muzna Hashmi, Arjumand Rizvi, Muhammad Sajid, Unab Khan, Saleema Gulzar, Imran Ahmed Chauhadry, Jai K. Das, Helen Howard, Sarah Jose, Katrien Janin, Julia Robinson

PMC · DOI: 10.1371/journal.pgph.0006162 · PLOS Global Public Health · 2026-03-26

## TL;DR

This study finds that over half of adolescent girls in a rural Pakistani district suffer from primary dysmenorrhea, with lifestyle and hygiene factors playing a key role.

## Contribution

The study provides novel insights into PD prevalence and its associations in rural Pakistani adolescents using a representative sample and adjusted statistical models.

## Key findings

- 60.4% of adolescent girls in Tando Mohammad Khan reported primary dysmenorrhea.
- Higher BMI was associated with reduced odds of PD, while physical inactivity and poor sleep increased PD risk.
- Menstrual hygiene practices like pad reuse and frequency of changing pads significantly influenced PD odds.

## Abstract

Primary dysmenorrhea (PD) is prevalent among adolescent girls but understudied in rural Pakistan. This study examines the prevalence of PD and its associated factors among girls aged 10–19 in a rural district of Pakistan. A cross-sectional survey was conducted in the district of Tando Mohammad Khan (TMK) among post-menarchal girls aged 10–19 using a multistage cluster random sampling. Analyses were conducted using STATA 15.0, with multivariable logistic regression adjusted for survey weights. Among 405 participants, 60.4% (95% CI [54–66]) reported PD. Higher body mass index was associated with reduced odds (overweight/obese: AOR = 0.3, 95% CI [0.1–0.9]), while lifestyle factors like physical inactivity (AOR = 1.8, 95% CI [1.2–2.9]) and inadequate sleep (AOR = 2.4, 95% CI [1.2–3.8]), increased PD odds. Dietary intake data suggested that each 10 g increase in carbohydrate slightly raised (AOR = 1.0, 95% CI [0.9–1.1]), whereas every 1 mg increase in vitamin B6 reduced PD odds (AOR = 0.9, 95% CI [0.8–0.9]). Menstrual hygiene practices like changing pads less frequently than 6 hours increased PD odds (AOR = 2.1, 95% CI [1.3–3.4]), while cloth pad reuse was associated with lower odds (AOR = 0.6, 95% CI [0.4–1.0]). PD prevalence is high among adolescents in TMK, with higher BMI linked to reduced PD odds, while diet, lifestyle, and menstrual hygiene significantly influence menstrual health. Further research is needed to guide targeted interventions for adolescent girls’ well-being and to promote gender equity.

## Linked entities

- **Diseases:** primary dysmenorrhea (MONDO:1060206)

## Full-text entities

- **Diseases:** pain (MESH:D010146), Dysmenorrhea (MESH:D004412), food insecurity (MESH:D005517), insulin resistance (MESH:D007333), infection (MESH:D007239), school absenteeism (MESH:D010698), Depression (MESH:D003866), obese (MESH:D009765), Nutritional deficiencies (MESH:D044342), underweight (MESH:D013851), inflammation (MESH:D007249), stunted (MESH:D006130), Inadequate sleep (MESH:D012892), reproductive disease (MESH:D060737), Overweight (MESH:D050177), functional (MESH:D003291), Symptom (MESH:D012816)
- **Chemicals:** iron (MESH:D007501), progesterone (MESH:D011374), zinc (MESH:D015032), cortisol (MESH:D006854), prostaglandin (MESH:D011453), calcium (MESH:D002118), Katrien (-), vitamin A (MESH:D014801), vitamin B12 (MESH:D014805), carbohydrate (MESH:D002241), vitamin C (MESH:D001205), vitamin D (MESH:D014807), Vitamin B6 (MESH:D025101), melatonin (MESH:D008550), magnesium (MESH:D008274), folate (MESH:D005492), Omega-3 fatty acid (MESH:D015525)
- **Species:** Homo sapiens (human, species) [taxon 9606], Anchoa mitchilli (bay anchovy, species) [taxon 224718], Nicotiana tabacum (American tobacco, species) [taxon 4097], Meleagris gallopavo (common turkey, species) [taxon 9103], Clupeonella grimmi (species) [taxon 2934022], Solanum tuberosum (potatoes, species) [taxon 4113]
- **Cell lines:** Line 145 — Homo sapiens (Human), Induced pluripotent stem cell (CVCL_JU27)

## Full text

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## Figures

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## References

51 references — full list in the complete paper: https://tomesphere.com/paper/PMC13020788/full.md

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Source: https://tomesphere.com/paper/PMC13020788