# Steroid‐Induced Takotsubo Cardiomyopathy in a Patient With Immune Thrombocytopenic Purpura

## TL;DR

A patient developed Takotsubo cardiomyopathy after receiving dexamethasone, suggesting steroids can trigger this heart condition even without typical stressors.

## Contribution

Identifies dexamethasone as a potential non-traditional trigger for Takotsubo cardiomyopathy in patients without emotional or physical stressors.

## Key findings

- Takotsubo cardiomyopathy onset was temporally linked to dexamethasone administration.
- The diagnosis was supported by coronary imaging and absence of alternate stressors.
- Steroid-induced catecholaminergic upregulation is proposed as a biological mechanism.

## Abstract

This case report highlights a temporal relationship between dexamethasone administration and the onset of Takotsubo cardiomyopathy, underscoring the importance of recognizing pharmacologic agents as potential non‐traditional triggers, particularly in patients with underlying cardiovascular disease and no identifiable emotional or physical stressors. Diagnosis favored a dexamethasone‐triggered Takotsubo phenotype based on non‐obstructive coronaries, regional wall‐motion abnormalities extending beyond a single arterial territory, absence of alternate stressors, and biologic plausibility of steroid‐mediated catecholaminergic upregulation.