Sex-specific prognostic value of triceps skinfold thickness and albumin in pancreatic cancer
Young Hoon Choi, Sang Ah Chi, Kyunga Kim, Jong-In Chang, Hyemin Kim, Dong Kee Jang, Se-Hoon Lee, Jong Kyun Lee, Kyu Taek Lee, Kwang Hyuck Lee, Joo Kyung Park
TL;DR
The study found that changes in body fat and albumin levels over six months are linked to survival in pancreatic cancer patients, with different patterns for males and females.
Contribution
The study introduces sex-specific prognostic models using triceps skinfold thickness and albumin in pancreatic cancer.
Findings
Reduced triceps skinfold thickness over six months is linked to shorter survival in males.
Lower baseline albumin and greater albumin decline are associated with poorer outcomes in females.
Changes in triceps skinfold thickness, albumin, and protein levels predict survival after chemotherapy.
Abstract
This study evaluated how triceps skinfold thickness, reflecting body fat, and serum albumin levels, indicating nutritional status, relate to overall survival in patients with pancreatic cancer receiving chemotherapy. We prospectively evaluated 353 patients with pancreatic cancer, repeatedly measuring triceps skinfold thickness and serum albumin from baseline through follow-up. Survival was assessed through a six-month landmark analysis and sex-stratified evaluations. Changes in triceps skinfold thickness, albumin, and protein levels over six months, as well as baseline albumin levels, were independently associated with survival. Cancer stage, chemotherapy response, and six-month CA19-9 levels also contributed to prognosis. Sex-specific analyses showed that reduced triceps skinfold thickness over six months was linked to shorter survival in males, whereas lower baseline albumin levels…
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Taxonomy
TopicsLymphatic System and Diseases · Inflammatory Biomarkers in Disease Prognosis · Nutrition and Health in Aging