Transdermal needle-free drug delivery approaches and activation mechanism
Apoorva Sasikala, Du Tuan Tran, Jun Zhang, Nam-Trung Nguyen
TL;DR
This review explores new non-needle methods for delivering drugs through the skin, focusing on how they work and their potential for personalized healthcare.
Contribution
The paper provides a critical review of recent advancements in physical transdermal drug delivery methods and their activation mechanisms.
Findings
Needle-free TDD technologies use various physical methods like spring-based and laser-induced mechanisms to enhance drug penetration.
These technologies offer improved safety and precision, supporting wearable and personalized healthcare applications.
Future directions include clinical translation and real-world deployment of these innovative drug delivery systems.
Abstract
The evolution of transdermal drug delivery (TDD) systems has transformed non-invasive drug delivery by improving safety, precision, and patient compliance. While conventional TDD methods face challenges with penetration efficiency and dosage control, needle-free transdermal drug delivery technologies are emerging as a promising alternative. This review critically examines recent advancements in transdermal needle-free drug delivery technologies, focusing on different physical penetration methods and activation mechanisms such as spring-based, gas-driven, electrochemical, piezoelectric, laser-induced and electromagnetic approaches, which generate sufficient force for increasing the penetration ability of the drugs through the stratum corneum. The paper also discusses the implications of these technologies for wearable and personalised healthcare, highlighting future directions for…
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Taxonomy
TopicsAdvancements in Transdermal Drug Delivery · 3D Printing in Biomedical Research · Advanced Sensor and Energy Harvesting Materials