Advances in pH‐Sensitive Luminescent Transition Metal Complexes for Theranostic Applications
Bishnu Das, Sakira Tabassum Borah
TL;DR
This paper reviews recent progress in pH-sensitive luminescent metal complexes for sensing and cancer treatment.
Contribution
The first comprehensive review connecting luminescence modulation with theranostic function in pH-sensitive transition metal complexes.
Findings
pH changes significantly affect luminescence through protonation and charge-transfer processes.
Ruthenium(II) complexes are highlighted for their tunable properties and suitability in biological environments.
Design strategies for reliable pH sensing and imaging are outlined based on mechanistic insights.
Abstract
pH sensitive luminescent transition metal complexes are emerging as next generation molecular probes for sensing, bioimaging, and cancer theranostics. Small variations in protonation state can markedly influence their photophysical behavior by modulating charge‐transfer processes, excited‐state energetics, and noncovalent interactions, resulting in pronounced and often reversible changes in emission intensity or wavelength. In this review, we examine recent advances in the design of pH‐responsive luminescent transition metal complexes and discuss the mechanistic origins of their pH sensitivity, including protonation‐deprotonation equilibria, hydrogen‐bonding effects, and aggregation‐induced phenomena. Particular emphasis is placed on ruthenium(II) and related complexes, which offer long‐lived excited states, structural robustness, and wide tunability through rational ligand design. We…
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Taxonomy
TopicsMolecular Sensors and Ion Detection · Analytical Chemistry and Sensors · Supramolecular Chemistry and Complexes