The correlation between characteristics and pharmacological effects of monoterpene glycosides and tannins in Radix Paeoniae Alba
Qitong Zheng, Mengyao Chen, Jialiang Ying, Zhichao Wang, Qiyuan Shan, Xia-Nan Sang, Gang Cao
TL;DR
This study explores how two compounds in Radix Paeoniae Alba, monoterpene glycosides and tannins, contribute to its medicinal effects despite their poor absorption in the body.
Contribution
The study systematically reviews the pharmacological roles and mechanisms of monoterpene glycosides and tannins in Radix Paeoniae Alba, emphasizing their distinct bioavailability and effects.
Findings
Monoterpene glycosides and tannins in Radix Paeoniae Alba have poor bioavailability due to gut metabolism and hydrophobicity.
Monoterpene glycosides exert anti-inflammatory, immunomodulatory, and neuromodulatory effects after intestinal absorption.
Tannins remain localized in the digestive system due to their inability to cross the intestinal barrier.
Abstract
The pharmacodynamic material basis constitutes the central element of traditional Chinese medicine (TCM) in disease treatment. By summarizing the active compounds' characteristics, bioavailability, pharmacological effects, and molecular mechanisms, we can explain the complex interactions between TCMs and diseases. Previous studies have demonstrated that monoterpene glycosides and tannins are related to the pharmacological activity of Radix Paeoniae Alba (RPA). However, research on RPA has primarily focused on monoterpene glycosides, and the functional role of tannins in RPA has received little attention. Observations from animal studies indicate that monoterpene glycosides and tannins exhibit poor bioavailability. Carboxylesterase, produced by gut microbiota, is crucial for metabolizing these compounds in the intestine. Monoterpene glycosides and their gut metabolites can be absorbed…
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Taxonomy
TopicsNatural product bioactivities and synthesis · Traditional Chinese Medicine Analysis · Ginseng Biological Effects and Applications