Gender differences in outcomes among patients with heart failure and preserved ejection fraction: A retrospective cohort study

TL;DR

This study finds that women with heart failure and preserved ejection fraction have better outcomes than men despite different risk factors.

Contribution

The study highlights gender-based differences in HFpEF outcomes and risk profiles, emphasizing the need for gender-sensitive clinical approaches.

Findings

Female patients were more often obese or hypertensive, while males had more coronary artery disease.

Females had lower mortality and hospitalization rates at one year despite differing risk profiles.

The findings suggest gender-specific variations in HFpEF outcomes require tailored clinical strategies.

Abstract

Gender differences in the clinical presentation and outcomes of heart failure with preserved ejection fraction (HFpEF) remain
inadequately characterized. This retrospective cohort study evaluated 146 HFpEF patients to compare baseline features and one-year
outcomes between males and females. Female patients were more frequently obese or hypertensive, whereas male patients more often had
coronary artery disease. Despite these differing risk profiles, females exhibited lower mortality and all-cause hospitalization rates at
one year. These findings underscore meaningful gender-based variations in HFpEF and support the need for gender-sensitive strategies in
clinical management and prognostication.