Evaluation of antioxidant enzyme activity among Indian patients with type 2 diabetes mellitus

TL;DR

This study found that antioxidant enzyme activity is lower in Type 2 Diabetes patients with poor blood sugar control, suggesting a link between oxidative stress and disease management.

Contribution

The study identifies reduced antioxidant enzyme activity in T2DM patients with poor glycemic control, offering new insights into oxidative stress management.

Findings

Significantly lower antioxidant enzyme activity was found in patients with poor glycemic control (HbA1c ≥ 7%).

Negative correlations were observed between antioxidant enzyme levels and HbA1c and fasting blood glucose.

Reduced enzyme activity suggests a potential role in managing oxidative stress in T2DM.

Abstract

Oxidative stress is a key factor in the pathogenesis of Type 2 Diabetes Mellitus (T2DM), and the role of antioxidant enzymes in
managing this stress remains an important area of research. Therefore, it is of interest to investigate the activity of antioxidant
enzymes (SOD, CAT and GPx) in patients with Type 2 Diabetes Mellitus (T2DM) to understand the relationship between glycemic control and
oxidative stress. We found significantly lower enzyme activity in individuals with poor glycemic control (HbA1c ≥ 7%) compared to those
with better control (HbA1c < 7%). Negative correlations were observed between antioxidant enzyme levels and clinical variables such as
HbA1c and fasting blood glucose. Our findings suggest that antioxidant enzyme activity may play a crucial role in managing oxidative
stress in T2DM. Further studies should explore the potential of antioxidant-based therapies. The advancement to knowledge in this study
is the identification of reduced antioxidant enzyme activity in patients with poor glycemic control, highlighting its potential role in
managing oxidative stress in Type 2 Diabetes Mellitus.