Cutaneous adverse drug reactions: A prospective observational study at a tertiary care hospital in Central India

TL;DR

This study examines skin reactions caused by medications at a hospital in India, finding that nonsteroidal anti-inflammatory drugs are a common cause.

Contribution

The study provides new insights into the patterns and causes of drug-induced skin reactions in a specific Indian hospital setting.

Findings

Fixed drug eruptions caused by NSAIDs were the most frequent cutaneous adverse drug reactions observed.

Self-medication was identified as a prevalent factor contributing to these adverse reactions.

The study emphasizes the need for improved pharmacovigilance and stricter regulations to reduce CADRs.

Abstract

Cutaneous adverse drug reactions (CADRs) are a common and significant concern, arising from both immunological and non-immunological
mechanisms. Therefore, it is of interest to identify the incidence, patterns and drug associations of CADRs at a tertiary care hospital
in Vidisha, Madhya Pradesh. A total of 56 cases were observed with fixed drug eruptions (FDEs) caused by NSAIDs being the most frequent.
The findings highlight the prevalent role of self-medication and the need for strict regulations, with improved pharmacovigilance to
mitigate these adverse reactions.