# Effect of dexmedetomidine, lignocaine and combination infusion for postoperative outcomes in abdominal surgery

**Authors:** Monika Gandhi, Shreya Chourasia, Aseem Sharma, Shailendra Singh, Shalini Jain

PMC · DOI: 10.6026/973206300214621 · 2025-12-15

## TL;DR

This study compares the effects of dexmedetomidine, lignocaine, and their combination on postoperative pain and recovery after abdominal surgery.

## Contribution

The novel finding is that combining dexmedetomidine and lignocaine provides better pain relief and faster recovery than either drug alone.

## Key findings

- The combination group had the lowest pain scores at 24 and 48 hours.
- Patients in the combination group used less analgesic medication.
- The combination group showed the best recovery outcomes.

## Abstract

Acute postoperative pain causes stress response and delays patient recovery after abdominal surgery. Therefore, it is of interest to
evaluate the effect of intravenous dexmedetomidine, lignocaine and their combination on postoperative pain and recovery under general
anesthesia. Ninety patients undergoing abdominal surgery were observed and assessed using NRS and QoR-15 at 24 and 48 hours. Combination
group showed lowest pain score, least analgesic use and best recovery indicating superior analgesic benefit with combined use.

## Linked entities

- **Chemicals:** dexmedetomidine (PubChem CID 5311068), lignocaine (PubChem CID 3676)

## Full-text entities

- **Diseases:** pain (MESH:D010146), postoperative pain (MESH:D010149)
- **Chemicals:** lignocaine (MESH:D008012), dexmedetomidine (MESH:D020927)
- **Species:** Homo sapiens (human, species) [taxon 9606]

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Source: https://tomesphere.com/paper/PMC13018376