D-dimer levels in acute exacerbation of asthma among children: A correlation study

TL;DR

This study finds that D-dimer levels in children correlate with asthma exacerbation severity and hospital stay duration.

Contribution

The study introduces D-dimer as a potential biomarker for assessing asthma exacerbation severity in children.

Findings

D-dimer positivity increases with asthma exacerbation severity in children.

Positive D-dimer results are strongly linked to longer hospital stays.

Abstract

Asthma exacerbations in children may involve systemic coagulation changes reflected by elevated D-dimer levels. Therefore, it is of
interest to evaluate 50 children aged 2-15 years to assess the correlation between D-dimer levels and acute exacerbation severity.
D-dimer positivity increased significantly with severity-from 9.5% (mild) to 45.5% (moderate) and 71.4% (severe) (p=0.004). Positive
D-dimer results were also strongly associated with longer hospital stays (p<0.001). Thus, we show that D-dimer is a valuable biomarker
for assessing exacerbation severity and predicting clinical outcomes in pediatric asthma.