Correlation of troponin I and CK-MB with COVID-19 severity in seriously ill patients: A retrospective analysis from medical records

TL;DR

This study found that higher levels of troponin I and CK-MB in seriously ill COVID-19 patients are linked to more severe disease.

Contribution

The study establishes a strong correlation between elevated troponin I and CK-MB levels and disease severity in hospitalized COVID-19 patients.

Findings

Severe COVID-19 cases had significantly higher cTnI and CK-MB levels (p < 0.001).

Elevated biomarker levels at admission correlate with disease severity in seriously ill patients.

Troponin I and CK-MB serve as early prognostic indicators for risk assessment in COVID-19.

Abstract

COVID-19 is frequently associated with cardiovascular complications, with cardiac troponin I (cTnI) and CK-MB serving as markers of
myocardial injury. Therefore, it is of interest to analyse of medical records from 300 PCR-confirmed COVID-19 patients admitted to High
Dependency Unit (HDU) and Intensive Care Unit (ICU) during the second wave (2020-2021), biomarker levels at admission were correlated with
disease severity. All patients included were seriously ill but survived. Severe cases had significantly higher cTnI and CK-MB levels
(p < 0.001). These biomarkers provide important early prognostic information For the purpose of risk assessment and therapeutic treatment
of COVID-19.