New frontiers in oral submucous fibrosis: The promise of collagen based interventions

TL;DR

This paper explores new collagen-based treatments for oral submucous fibrosis, a chronic disease causing fibrosis in the mouth.

Contribution

The paper introduces collagen-based interventions as a novel approach to treat oral submucous fibrosis.

Findings

Collagen metabolism abnormalities are central to the progression of oral submucous fibrosis.

Collagen-based therapies offer potential to reverse fibrotic changes and improve outcomes.

Combining collagen-based treatments with regenerative medicine shows promise for managing the disease.

Abstract

Oral Sub-mucous Fibrosis (OSMF) is a chronic, progressive and potentially malignant disorder characterized by inflammation and fibrosis of
the oral mucosa, often leading to significant morbidity and impaired quality of life. The pathogenesis of OSMF is strongly associated with
abnormal collagen metabolism, resulting in excessive deposition and reduced degradation of collagen fibres. Traditional therapeutic modalities
have shown limited success in reversing the fibrotic changes, underscoring the need for novel treatment approaches. Therefore, it is of interest
to explore the emerging role of collagen-based interventions including modulation therapies, enzymatic degradation, and regenerative techniques)
which target key molecular pathways to improve functional outcomes and arrest disease progression. The potential of combining collagen- based
approaches with regenerative and personalized medicine in the effective management of OSMF is also promising.