# Editorial Expression of Concern: Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation

**Authors:** Xiaohong Tan, Lu Tong, Lin Li, Jinjin Xu, Shaofang Xie, Lei Ji, Junjiang Fu, Qingwu Liu, Shihui Shen, Yun Liu, Yanhui Xiao, Feiran Gao, Robb E. Moses, Nabeel Bardeesy, Yanxiao Wang, Jishuai Zhang, Longying Tang, Lei Li, Kwok-kin Wong, Dianwen Song, Xiao Yang, Jian Liu, Xiaotao Li

PMC · DOI: 10.1038/s41467-026-71023-9 · 2026-03-25

## Full-text entities

- **Genes:** JUN (Jun proto-oncogene, AP-1 transcription factor subunit) [NCBI Gene 3725] {aka AP-1, AP1, c-Jun, cJUN, p39}, SPHK1 (sphingosine kinase 1) [NCBI Gene 8877] {aka SPHK}, MIR543 (microRNA 543) [NCBI Gene 100126335] {aka MIRN543, hsa-mir-543, mir-543}, SMAD4 (SMAD family member 4) [NCBI Gene 4089] {aka DPC4, JIP, MADH4, MYHRS}, SYMPK (symplekin scaffold protein) [NCBI Gene 8189] {aka Pta1, SPK, SYM}, MAPK8 (mitogen-activated protein kinase 8) [NCBI Gene 5599] {aka JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8}, PAK3 (p21 (RAC1) activated kinase 3) [NCBI Gene 5063] {aka ARA, MRX30, MRX47, OPHN3, PAK-3, PAK3beta}
- **Diseases:** lung cancer metastasis (MESH:D008175)

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Source: https://tomesphere.com/paper/PMC13018171