Resolving tooth development at single-cell resolution: advancing dental regeneration
Chengcheng Liao, Jun Cai, Yanmei Liu, Linlin Xiao, Mingli Xiang, Man Qu, Qian Long, Meiling Xiang, Sicen Long, Houli Peng, Jianguo Liu, Xiaoyan Guan
TL;DR
This paper explores tooth development using single-cell techniques to better understand organ formation and improve dental regeneration.
Contribution
The paper highlights how single-cell transcriptomics advance understanding of tooth development and regeneration strategies.
Findings
Single-cell transcriptomics reveal cellular heterogeneity in tooth development.
Lineage trajectories and signaling networks are better understood through these techniques.
Findings provide a foundation for dental tissue regeneration strategies.
Abstract
Tooth development is a continuous, highly orchestrated process that serves as an ideal model for dissecting the cellular and molecular mechanisms of organogenesis. In recent years, advances in single-cell transcriptomics have provided unprecedented insights into cellular heterogeneity, lineage trajectories, and molecular signaling networks during mouse and human tooth development, greatly enhancing our understanding of odontogenesis. Crucially, these single-cell-level studies of tooth development provide both a theoretical foundation and advanced strategies for dental tissue regeneration.
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
Topicsdental development and anomalies · Bone and Dental Protein Studies · Dental Trauma and Treatments