# Dopaminergic manipulation modulates frequency-specific EEG connectivity patterns: evidence from a single dose drug challenge study

## TL;DR

This study shows how dopaminergic drugs affect brain connectivity patterns in healthy people, offering insights into their role in treating psychotic disorders.

## Contribution

The study provides empirical evidence of how dopaminergic drugs modulate frequency-specific EEG connectivity in healthy individuals.

## Key findings

- Phase ICMs showed a linear increase in delta frequency and decrease in low-beta frequency with drug conditions.
- Gamma phase ICMs were significantly reduced in both drug conditions compared to placebo.
- Alpha and low-beta envelope ICMs showed a linear decrease from L-dopa to haloperidol.

## Abstract

Dysregulation in resting-state connectivity in electroencephalogram (EEG) and dysregulation in the dopamine system have both been repeatedly observed in patients with psychotic disorders. It is unclear whether dopaminergic drugs, used to treat psychotic disorders, induce treatment-relevant connectivity changes in the brain. Investigating the effects of dopaminergic drugs in healthy participants could provide crucial insights into how dopaminergic modulation directly influences resting-state connectivity.

In a randomized controlled crossover study including 58 healthy participants, we examined the effects of L-dopa (dopamine pre-cursor), haloperidol (dopamine D2 antagonist), and placebo on frequency-specific connectivity patterns (intrinsic coupling modes; ICMs). Source-space connectivity between brain regions was calculated for phase ICMs via multivariate interaction measure, and for envelope ICMs via orthogonalized power correlation.

Phase ICMs showed a significant linear increase (from L-dopa to placebo to haloperidol) in the delta frequency, and a significant linear decrease in the low-beta frequency. Gamma phase ICMs were significantly reduced in both drug conditions compared to placebo. Orthogonalized power correlation showed a significant linear decrease (from L-dopa to placebo to haloperidol), in the alpha and low-beta frequency.

Our findings in the gamma band support the long-standing hypothesis that dopaminergic action on large-scale neural networks follows an inverted U-shaped curve. The linear pattern of our findings in the delta, alpha, and low-beta frequency bands reflect possible relevant effects for psychotic symptoms. However, our findings are difficult to relate to existing findings in patients. Our results highlight the need for further prospective studies in patients to better understand the relationship between dopaminergic effects and ICMs.