# A Rapid Test to Differentiate Viral From Bacterial Infections: Searching for the Holy Grail

**Authors:** Lao-Tzu Allan-Blitz, Jeffrey D Klausner

PMC · DOI: 10.1093/cid/ciaf585 · Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America · 2025-10-24

## TL;DR

This paper reviews a rapid test combining two biomarkers to help distinguish viral from bacterial infections and reduce unnecessary antibiotic use.

## Contribution

The paper evaluates a combined point-of-care assay using Myxovirus resistance protein A and C-reactive protein for infection differentiation.

## Key findings

- The combined assay shows potential for rapid differentiation of viral and bacterial infections.
- Remaining questions include the test's accuracy and applicability in diverse clinical settings.

## Abstract

Differentiating viral from bacterial causes of acute respiratory illness can avoid the numerous consequences of inappropriate antibiotic use. We review the clinical literature evaluating a combined rapid Myxovirus resistance protein A and C-reactive protein point-of-care assay, discuss potential applications, and highlight remaining questions.

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** respiratory illness (MESH:D012140), Bacterial Infections (MESH:D001424)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC13017729/full.md

## References

40 references — full list in the complete paper: https://tomesphere.com/paper/PMC13017729/full.md

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Source: https://tomesphere.com/paper/PMC13017729