# Assessment of Concordant Human Papillomavirus Infection With 9-Valent Vaccine Types Across Anogenital Sites in Young Men

## TL;DR

This study found that men who have sex with men are more likely to have the same HPV infection at multiple anogenital sites compared to heterosexual men, with HPV6 and HPV16 being the most common.

## Contribution

The study quantifies the prevalence of concordant 9vHPV infection across multiple anogenital sites in young men, comparing heterosexual and men who have sex with men populations.

## Key findings

- Concordant 9vHPV infection at two anogenital sites was 3.7% in heterosexual men and 9.1% in men who have sex with men.
- HPV6 and HPV16 were most likely to occur at multiple anogenital sites in both groups.
- Strong agreement was observed between perineal/perianal and anal sites for HPV6 and HPV16 in men who have sex with men.

## Abstract

The global prevalence of and risk factors associated with same-type HPV infection across multiple anogenital sites among men has not been quantified.

Men aged 16–27 years participating in a multi-country 4-valent HPV vaccine trial (NCT00090285) were assessed at baseline for prevalent HPV infection at penile/scrotal and perineal/perianal sites (heterosexual men [HM] and men who have sex with men [MSM]) and additionally at intra-anal sites (MSM). Concordant infection with 9-valent HPV (9vHPV) vaccine types (6/11/16/18/31/33/45/52/58) was defined as same-type 9vHPV infection at 2 or 3 sites.

3363 HM and 595 MSM were included. Prevalence of concordant 9vHPV infection at 2 anogenital sites was 3.7% among HM and 9.1% among MSM, and 8.2% at 3 sites (including the intra-anal site) among MSM. HPV6 and HPV16 were most likely to occur at multiple anogenital sites in HM and MSM, with strong agreement observed between perineal/perianal and anal sites among MSM for HPV6 (Cohen's kappa, 0.78; 95% CI, .69–.87) and HPV16 (0.61; 95% CI, .50–.73).

Concordant anogenital 9vHPV infection was more common among MSM than HM, which is consistent with evidence that MSM are at increased risk of HPV-related cancer across multiple anogenital sites.

Clinical Trial Registration:  ClinicalTrials.gov, NCT00090285

Concordant anogenital HPV infection was more common in men who have sex with men than heterosexual men; HPV6 and HPV16 were most commonly detected

HPV vaccination may protect against initial HPV infection and acquisition of infections at other anogenital sites