# The value of artificial intelligence in ultrasound imaging for predicting molecular subtypes of breast cancer: a meta-analysis

## TL;DR

This study shows that AI combined with ultrasound imaging can accurately predict breast cancer subtypes, potentially reducing the need for biopsies.

## Contribution

Demonstrates the effectiveness of AI-enhanced ultrasound for predicting breast cancer molecular subtypes with high accuracy.

## Key findings

- AI-enhanced ultrasound has a pooled sensitivity of 0.89 and specificity of 0.82 for predicting breast cancer subtypes.
- The diagnostic odds ratio was 32.10, indicating strong diagnostic performance.
- The area under the curve was 0.91, suggesting high overall accuracy.

## Abstract

The study aims to integrate an evaluation of the accuracy and validity of ultrasonography based artificial intelligence (AI) algorithms for predicting the molecular subtypes of breast cancer patients through a meta-analysis.

A search of the PubMed, Embase, Web of Science, and Cochrane Library databases was performed to locate relevant literature, and the reported studies before February 2026 were included. We evaluated the quality of the studies included by utilizing the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) questionnaire. Two evaluators independently searched for literature and assessed the quality of literature included in the study.

A total of thirteen studies assessing a number of 13615 patients of breast cancer were included. The results demonstrated that ultrasonic imaging combined with artificial intelligence algorithm has promising accuracy and effectiveness to predict molecular subtypes of breast cancer. The pooled sensitivity and specificity were 0.89 (95%CI: 0.82-0.93) and 0.82 (95%CI: 0.77-0.86), respectively. Additionally, the diagnostic odds ratios (DOR), positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were 32.10 (95%CI: 18.60-55.38), 4.84 (95%CI:3.80-6.17), and 0.14 (95%CI: 0.09-0.22). The area under the curve (AUC) was 0.91 (95%CI: 0.88-0.93). Publication bias was not significantly observed.

Ultrasonic imaging based on artificial intelligence algorithm has good performance and application prospects for forecasting breast cancer molecular subtypes. This technique can help establish the molecular subtype of breast cancer before operation, offering effective help for the treatment plan. It may reduce unnecessary biopsy, which is anticipated to become a meaningful implement in clinical application.

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024599983, identifier CRD42024599983.