# Association between triglyceride glucose- systemic immune inflammation index and deep venous thrombosis in fresh fracture patient: a real-world retrospective study

## TL;DR

This study finds that a higher triglyceride-glucose systemic inflammation index (TyG-SII) is linked to a lower risk of deep vein thrombosis in patients with fresh fractures.

## Contribution

The study is the first to explore the association between TyG-SII and deep vein thrombosis in traumatic fracture patients.

## Key findings

- Patients with moderate and high TyG-SII levels had significantly lower DVT risk compared to those with low levels.
- A nonlinear U-shaped relationship was observed between TyG-SII and DVT risk.
- Maintaining a good TyG-SII index may help prevent DVT after traumatic fractures.

## Abstract

Currently, systemic inflammation indices and insulin resistance are both recognised as high-risk factors for venous thromboembolic diseases. However, there is a lack of research on the relationship between the triglyceride-glucose-systemic inflammation index (TyG-SII) and the risk of lower limb deep vein thrombosis (DVT) in populations with traumatic fractures. This study aims to investigate the relationship between TyG-SII and the risk of DVT.

The study participants were inpatients from the Orthopaedic Centre of Foshan Traditional Chinese Medicine Hospital. Participants were divided into three groups using K-means clustering analysis based on changes in TyG-SII. Multivariate binary logistic regression analysis was used to explore the association between different groups (based on different levels of TyG-SII and DVT. Restricted cubic spline (RCS) regression models were used to explore the potential nonlinear association between TyG-SII and DVT events. Receiver operating characteristic (ROC) curves were employed to quantify the predictive ability of TyG-SII for DVT. Subgroup analyses further confirmed the relationship between TyG-SII and DVT in different populations.

Among the 5,455 patients, 1,991 (36.50%) developed DVT, and 646 (11.84%) developed only MCVT. After adjusting for various potential confounding factors, patients with moderate (OR = 0.86, 95% CI: 0.66–0.98) and high levels of TyG-SII had a significantly lower risk of DVT compared to those with low levels of TyG-SII (OR = 0.73, 95% CI: 0.58–0.95). Compared with the lowest quartile (Q1) of baseline TyG-SII, the third quartile (Q3) showed the most significant protective effect (OR = 0.46, 95% CI: 0.39–0.55). Additionally, there was a nonlinear U-shaped relationship between baseline TyG-SII and DVT risk, with thresholds of 242.14 and 3710.98, respectively.

For patients with traumatic fractures, TyG-SII is independently associated with the risk of lower limb DVT. Maintaining a good TyG-SII index helps prevent the occurrence of DVT after traumatic fractures.